S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica
- Lee, Min-Won; Kim, Jung-Hwan; Jeong, Dong-Wook; Ahn, Kyoung-Hwan; Toh, Sang-Hak; Surh, Young-Joon
- Issue Date
- Biological and Pharmaceutical Bulletin, Vol.23 No.4, pp.517-518
- Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranoside and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydrosxphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells.
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