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Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica

Cited 49 time in Web of Science Cited 63 time in Scopus
Authors

Lee, Min-Won; Kim, Jung-Hwan; Jeong, Dong-Wook; Ahn, Kyoung-Hwan; Toh, Sang-Hak; Surh, Young-Joon

Issue Date
2000-04
Publisher
Pharmaceutical Society of Japan
Citation
Biological and Pharmaceutical Bulletin, Vol.23 No.4, pp.517-518
Abstract
Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranoside and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydrosxphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells.
ISSN
0918-6158
URI
https://hdl.handle.net/10371/172640
DOI
https://doi.org/10.1248/bpb.23.517
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  • College of Pharmacy
  • Department of Pharmacy
Research Area Agricultural Sciences

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