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Evaluation of Anti-Colitic Effect of Chung-Jang-Hwan (C-mix) in Mice

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Authors
Lee, Hoyong; Ahn, Young-Tae; Park, Se-Hoon; Ahn, Young Min; Shim, Jae-Jung; Lee, Jung-Hee; Lee, Jeong-Sang; Surh, Young-Joon; Huh, Chul-Sung; Kim, Dong-Hyun
Issue Date
2011-01
Citation
Biomolecules & Therapeutics, Vol.19 No.1, pp.52-58
Keywords
Chung-Jang-HwanC-mixColitisInflammationMicroarray
Abstract
The inhibitory effect of Chung-Jang-Hwan (C-mix) consisted of Geranium nepalense subsp. thunbergii, Saururus chinensis, and Rubus coreanus were investigated in dextran sulfate sodium (DSS)-induced colitic mice by microarray analysis. Treatment with C-mix improved colitic symptoms, including colon shortening and myeloperoxidase activity. Treatment with DSS alone upregulated the expression levels of inflammation-related genes, including IL-1 beta, IL-6, CCL2, CCL4, CCL5, CCL7, CCL8, CCL24, CXCL1, CXCL2, CXCL5, CXCL9 and CXCL10, and other colitis-related genes such as COX-2, PAP, MMP family, S100a8, S100a9 and DEFA1 in mice. However, treatment with C-mix inhibited the expression levels of inflammation-associated genes induced by DSS. The increased expression levels of COX-2 and IL-1 beta, representative inflammatory genes, were confirmed by a quantitative real-time polymerase chain reaction analysis. These results indicate that C-mix may ameliorate colitis by the inhibitory regulation of inflammation-associated genes.
ISSN
1976-9148
URI
https://hdl.handle.net/10371/172643
DOI
https://doi.org/10.4062/biomolther.2011.19.1.052
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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