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Induction of apoptosis by quercetin is mediated through AMPK α1/ASK1/p38 pathway

Cited 60 time in Web of Science Cited 65 time in Scopus
Authors
Lee, Yun-Kyoung; Hwang, Jin-Taek; Kwon, Dae Young; Surh, Young-Joon; Park, Ock Jin
Issue Date
2010-06
Citation
Cancer Letters, Vol.292 No.2, pp.228-236
Keywords
ROSQuercetinASK1AMPK alpha 1Apoptosis
Abstract
Effective strategies for cancer prevention and treatment can be identified by understanding the mechanism of apoptotic pathways. In this study, we investigated the regulatory mechanism of quercetin-induced apoptosis through apoptosis signal-regulating kinase (ASK)-1 and mitogen-activated protein kinase pathways Our results showed that quercetin increased apoptotic cell death through reactive oxygen species (ROS) generation and was responsible for ASK1 activation. Increasing ASK1 activity was accompanied by p38 activation Interestingly, AMP-activated protein kinase (AMPK) seemed to be a critical controller of quercetin-regulated ASK1/p38 activation. Blocking AMPK alpha 1 activity using Compound C, a synthetic inhibitor or siRNA showed that quercetin-activated ASK1 could not stimulate p38 activity. Thus, we suggested that quercetin-exerted apoptotic effects involve ROS/AMPK alpha 1/ASK1/p38 signaling pathway, and AMPK alpha 1 is a necessary element for apoptotic event induced by ASK1 (C) 2009 Elsevier Ireland Ltd All rights reserved.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172645
DOI
https://doi.org/10.1016/j.canlet.2009.12.005
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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