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Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Cheon | - |
dc.contributor.author | Kang, Kyoung Ah | - |
dc.contributor.author | Zhang, Rui | - |
dc.contributor.author | Piao, Mei Jing | - |
dc.contributor.author | Kim, Gi Young | - |
dc.contributor.author | Kang, Mi Young | - |
dc.contributor.author | Lee, Su Jae | - |
dc.contributor.author | Lee, Nam Ho | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Hyun, Jin Won | - |
dc.date.accessioned | 2021-01-31T09:24:28Z | - |
dc.date.available | 2021-01-31T09:24:28Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | International Journal of Biochemistry and Cell Biology, Vol.42 No.2, pp.297-305 | - |
dc.identifier.issn | 1357-2725 | - |
dc.identifier.other | 2677 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172647 | - |
dc.description.abstract | The aim of the present study was to examine the cytoprotective effect of eckol, a phlorotannin found in Ecklonia cava and to elucidate underlying mechanisms. Heme oxygenase-1 (HO-1) is an important antioxidant enzyme that plays a role in cytoprotection against oxidative stress. Eckol-induced HO-1 expression both at the level of mRNA and protein in Chinese hamster lung fibroblast (V79-4) cells, resulting in increased HO-1 activity. The transcription factor NF-E2-related factor 2 (Nrf2) is a critical regulator of HO-1, achieved by binding to the antioxidant response element (ARE). Eckol treatment resulted in the enhanced level of phosphorylated form, nuclear translocation, ARE-binding, and transcriptional activity of Nrf2. Extracellular regulated kinase (Erk) and phosphaticylinositol 3-kinase (PI3K)/protein kinase B (PKB, Akt) contributed to ARE-driven HO-1 expression. Eckol activated both Erk and Akt, and treatments with U0126 (an Erk kinase inhibitor), LY294002 (a PI3K inhibitor), specific Erk1 siRNA, and Akt siRNA suppressed the eckol-induced activation of Nrf2, resulting in a decrease in HO-1 expression. ZnPP (a HO-1 inhibitor), HO-1 siRNA, and Nrf2 siRNA markedly abolished the cytoprotective effect of eckol against hydrogen peroxide-induced cell damage. Likewise, U0126 and LY294002 inhibited the eckol-induced cytoprotective effect against oxidative cell damage. These studies demonstrate that eckol attenuates oxidative stress by activating Nrf2-mediated HO-1 induction via Erk and PI3K/Akt signaling. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.biocel.2009.11.009 | - |
dc.citation.journaltitle | International Journal of Biochemistry and Cell Biology | - |
dc.identifier.wosid | 000274718600016 | - |
dc.identifier.scopusid | 2-s2.0-73749083990 | - |
dc.citation.endpage | 305 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 297 | - |
dc.citation.volume | 42 | - |
dc.identifier.sci | 000274718600016 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIOXIDANT RESPONSIVE ELEMENT | - |
dc.subject.keywordPlus | NRF2 TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | IONIZING-RADIATION | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | BILIRUBIN | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | Eckol | - |
dc.subject.keywordAuthor | Heme oxygenase-1 | - |
dc.subject.keywordAuthor | NF-E2-related factor 2 | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Cytoprotection | - |
dc.subject.keywordAuthor | Extracellular regulated kinase | - |
dc.subject.keywordAuthor | Phosphatidylinositol 3-kinase | - |
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