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Breaking the NF-kB and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis

Cited 13 time in Web of Science Cited 14 time in Scopus
Authors
Surh, Young-Joon; Bode, Ann M.; Dong, Zigang
Issue Date
2010-11
Citation
Cancer Prevention Research, Vol.3 No.11, pp.1379-1381
Abstract
This perspective on Liby et al. (beginning on page 1427 in this issue of the journal) discusses the importance of the finding that two synthetic triterpenoids prolonged survival in a pancreatic cancer mouse model. This finding is significant because pancreatic cancer is one of the deadliest human cancers. These compounds inhibited the interaction between NF-kappa B and signal transducer and activator of transcription 3, and determining the mechanisms underlying this inhibition will help to rapidly move these compounds into phase I clinical trials. Cancer Prev Res; 3(11); 1379-81. (C) 2010 AACR.
ISSN
1940-6207
URI
https://hdl.handle.net/10371/172651
DOI
https://doi.org/10.1158/1940-6207.CAPR-10-0251
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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