S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Breaking the NF-kB and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis
- Surh, Young-Joon; Bode, Ann M.; Dong, Zigang
- Issue Date
- Cancer Prevention Research, Vol.3 No.11, pp.1379-1381
- This perspective on Liby et al. (beginning on page 1427 in this issue of the journal) discusses the importance of the finding that two synthetic triterpenoids prolonged survival in a pancreatic cancer mouse model. This finding is significant because pancreatic cancer is one of the deadliest human cancers. These compounds inhibited the interaction between NF-kappa B and signal transducer and activator of transcription 3, and determining the mechanisms underlying this inhibition will help to rapidly move these compounds into phase I clinical trials. Cancer Prev Res; 3(11); 1379-81. (C) 2010 AACR.
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