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Resveratrol and Piceatannol Inhibit iNOS Expression and NF-B Activation in Dextran Sulfate Sodium-Induced Mouse Colitis : Resveratrol and Piceatannol Inhibit iNOS Expression and NF-kappa B Activation in Dextran Sulfate Sodium-Induced Mouse Colitis
Cited 103 time in
Web of Science
Cited 108 time in Scopus
- Authors
- Issue Date
- 2009-11
- Publisher
- Lawrence Erlbaum Associates Inc.
- Citation
- Nutrition and Cancer, Vol.61 No.6, pp.847-854
- Abstract
- Inflammatory tissue injury has been implicated in tumor promotion and progression. 3,5,4'-trihydroxy-trans-stilbene (resveratrol) and 3,4,3',5'-tetrahydroxy-trans-stilbene (piceatannol), 2 structurally related plant polyphenols, have been reported to possess antioxidant, anti-inflammatory, and chemopreventive properties. This study was aimed at investigating the possible protective effects of resveratrol and piceatannol against dextran sulfate sodium (DSS)-induced inflammation in mouse colonic mucosa. Administration of DSS (2.5%) in drinking water for 7 days to male ICR mice resulted in colitis and elevated expression of inducible nitric oxide synthase (iNOS) and activation of nuclear factor-kappa B (NF-kappa B), a major transcription factor known to upregulate proinflammatory gene expression. Phosphorylation of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription-3 (STAT3) was also enhanced after DSS treatment. Oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappa B, STAT3, and ERK.
- ISSN
- 0163-5581
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