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Resveratrol and Piceatannol Inhibit iNOS Expression and NF- B Activation in Dextran Sulfate Sodium-Induced Mouse Colitis

Cited 82 time in Web of Science Cited 88 time in Scopus
Authors
Youn, Jin; Lee, Jeong-Sang; Na, Hye-Kyung; Kundu, Joydeb Kumar; Surh, Young-Joon
Issue Date
2009-11
Citation
Nutrition and Cancer, Vol.61 No.6, pp.847-854
Abstract
Inflammatory tissue injury has been implicated in tumor promotion and progression. 3,5,4'-trihydroxy-trans-stilbene (resveratrol) and 3,4,3',5'-tetrahydroxy-trans-stilbene (piceatannol), 2 structurally related plant polyphenols, have been reported to possess antioxidant, anti-inflammatory, and chemopreventive properties. This study was aimed at investigating the possible protective effects of resveratrol and piceatannol against dextran sulfate sodium (DSS)-induced inflammation in mouse colonic mucosa. Administration of DSS (2.5%) in drinking water for 7 days to male ICR mice resulted in colitis and elevated expression of inducible nitric oxide synthase (iNOS) and activation of nuclear factor-kappa B (NF-kappa B), a major transcription factor known to upregulate proinflammatory gene expression. Phosphorylation of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription-3 (STAT3) was also enhanced after DSS treatment. Oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappa B, STAT3, and ERK.
ISSN
0163-5581
URI
https://hdl.handle.net/10371/172652
DOI
https://doi.org/10.1080/01635580903285072
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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