Browse

Modulation of tumor microenvironment by chemopreventive natural products

Cited 16 time in Web of Science Cited 15 time in Scopus
Authors
Park, Sin-Aye; Surh, Young-Joon
Issue Date
2017-08
Citation
Annals of the New York Academy of Sciences, Vol.1401 No.1, pp.65-74
Keywords
tumor microenvironmentcancer-associated fibroblaststumor-associated endothelial cellstumor-associated macrophagesmyeloid-derived suppressor cellstumor stroma
Abstract
The tumor microenvironment provides a niche in which cancer cells and their surrounding stromal cells reside and in which their interactions occur. The cross talk between cancer and stromal cells in the tumor microenvironment promotes many biological processes to support cancer cell growth, invasion, angiogenesis, and metastasis. Recently, not only cancer cells but also multiple types of surrounding stromal cells, including endothelial cells, immune cells, and fibroblasts in the tumor microenvironment, have been recognized to be attractive targets for reducing resistance to anticancer therapy and tumor recurrence. Many natural products present in fruits, vegetables, herbs, spices, and some marine organisms have been reported to inhibit, delay, or reverse multistage carcinogenesis and to inhibit the proliferation of cancerous cells and the self-renewal capacity of preexisting cancer stem-like cells. Some of these naturally occurring chemopreventive and anticarcinogenic substances can modulate the signal transduction involved in maintaining the activities/functions of stromal cells and their interactions with cancer cells within the tumor microenvironment.
ISSN
0077-8923
URI
https://hdl.handle.net/10371/172659
DOI
https://doi.org/10.1111/nyas.13395
Files in This Item:
There are no files associated with this item.
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse