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Chemoprotective properties of chlorophyllin against vinyl carbamate, p-nitrophenyl vinyl ether and their electrophilic epoxides

Cited 24 time in Web of Science Cited 23 time in Scopus
Authors
Park, Kwang-Kyun; Surh, Young-Joon; Miller, James A.
Issue Date
1995-07
Citation
Cancer Letters, Vol.94 No.1, pp.33-40
Keywords
CHLOROPHYLLINCHEMOPREVENTIONANTICARCINOGENESISANTIMUTAGENESISVINYL CARBAMATEP-NITROPHENYL VINYL ETHER
Abstract
Chlorophyllin (CHL), a water-soluble sodium and copper derivative of chlorophyll, has been shown to be a strong antimutagen in several test systems, but its mechanism of antimutagenic action is largely unknown. In the present study, we have found the protective properties of CHL against vinyl carbamate, p-nitrophenyl vinyl ether and their electrophilic epoxides. CHL exhibited dose-related inhibition of his(+) reversion in Salmonella typhimurium TA 1535 induced by these mutagens. Formation of DNA adducts from vinyl carbamate epoxide (VCO) and 2'-(4-nitrophenoxy)oxirane (NPO) was also markedly attenuated in the presence of CHL. Oral administration of CHL prior to the topical application of each of the above carcinogens resulted in significant reduction in both incidence and multiplicity of skin tumors in mice. The effective protection by CHL against VCO and NPO suggest that its formation of inactive complexes with these carcinogens is mediated by mechanisms other than pi-pi interactions.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172666
DOI
https://doi.org/10.1016/0304-3835(95)03822-E
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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