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Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-(12,14)-PGJ(2)

Cited 2 time in Web of Science Cited 1 time in Scopus
Authors
Kim, Kyeojin; Park, Jong-Min; Kim, Nam-Jung; Kim, Su-Jung; Moon, Hyunyoung; An, Hongchan; Lee, Jeeyeon; Park, Hyun-Ju; Surh, Young-Joon; Suh, Young-Ger
Issue Date
2016-10
Citation
ChemBioChem, Vol.17 No.20, pp.1900-1904
Keywords
15 deoxy-PGJ(2)biomimetic synthesischemical approachinhibitorsKeap1Michael additionNrf2
Abstract
Mechanism-based chemical transformation of 15-deoxy-(12,14)-PGJ(2) (15d-PGJ(2)) resulted in a series of new NF-E2-related factor-2 (Nrf2) activators and detailed elucidation of the function of each electrophilic binding site. In addition, HO-1 expression resulting from Nrf2 activation through enhanced dissociation of the Keap1-Nrf2 complex by the new activators was proved.
ISSN
1439-4227
URI
https://hdl.handle.net/10371/172667
DOI
https://doi.org/10.1002/cbic.201600165
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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