Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-(12,14)-PGJ(2)

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Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-(12,14)-PGJ(2)

Cited 2 time in Web of Science Cited 2 time in Scopus

Authors: Kim, Kyeojin; Park, Jong-Min; Kim, Nam-Jung; Kim, Su-Jung; Moon, Hyunyoung; An, Hongchan; Lee, Jeeyeon; Park, Hyun-Ju; Surh, Young-Joon; Suh, Young-Ger

Abstract: Mechanism-based chemical transformation of 15-deoxy-(12,14)-PGJ(2) (15d-PGJ(2)) resulted in a series of new NF-E2-related factor-2 (Nrf2) activators and detailed elucidation of the function of each electrophilic binding site. In addition, HO-1 expression resulting from Nrf2 activation through enhanced dissociation of the Keap1-Nrf2 complex by the new activators was proved.