Publications
Detailed Information
Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Miller, James A. | - |
dc.date.accessioned | 2021-01-31T09:26:16Z | - |
dc.date.available | 2021-01-31T09:26:16Z | - |
dc.date.created | 2019-10-18 | - |
dc.date.issued | 1994-06 | - |
dc.identifier.citation | Chemico-Biological Interactions, Vol.92 No.1-3, pp.351-362 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.other | 85291 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172675 | - |
dc.description.abstract | Hydroxylation of meso-methyl groups with subsequent formation of reactive benzylic esters bearing a good leaving group (e.g. sulfate) was proposed as a possible biochemical mechanism of activation and tumorigenicity of methyl-substituted polycyclic aromatic hydrocarbons (PAHs). In support of this postulation, recent studies have demonstrated the formation by. rodent hepatic sulfotransferase activity of electrophilic, mutagenic, and carcinogenic sulfuric acid esters of several hydroxymethyl aromatic hydrocarbons including hydroxymethyl derivatives of benz[a]anthracene, 6-hydroxymethylbenzo[a]pyrene, 5-hydroxymethylchrysene, 9-hydroxymethyl-10-methylanthracene, and 1-hydroxymethylpyrene. Besides these hydroxymethyl PAHs containing a primary benzylic alcoholic group, some aromatic hydrocarbons with secondary benzylic hydroxyl functional group(s) are also metabolically activated through sulfuric acid esterification. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/0009-2797(94)90076-0 | - |
dc.citation.journaltitle | Chemico-Biological Interactions | - |
dc.identifier.wosid | A1994PD13800030 | - |
dc.identifier.scopusid | 2-s2.0-0028307770 | - |
dc.citation.endpage | 362 | - |
dc.citation.number | 1-3 | - |
dc.citation.startpage | 351 | - |
dc.citation.volume | 92 | - |
dc.identifier.sci | A1994PD13800030 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SULFOTRANSFERASE-MEDIATED ACTIVATION | - |
dc.subject.keywordPlus | HEPATIC CORTISOL SULFOTRANSFERASE | - |
dc.subject.keywordPlus | 7-HYDROXYMETHYL SULFATE ESTER | - |
dc.subject.keywordPlus | BENZYLIC DNA ADDUCTS | - |
dc.subject.keywordPlus | MALE B6C3F1 MICE | - |
dc.subject.keywordPlus | CALF THYMUS DNA | - |
dc.subject.keywordPlus | HYDROXYSTEROID SULFOTRANSFERASE | - |
dc.subject.keywordPlus | RAT-LIVER | - |
dc.subject.keywordPlus | ACTIVE METABOLITE | - |
dc.subject.keywordPlus | COVALENT BINDING | - |
dc.subject.keywordAuthor | HYDROXYSTEROID SULFOTRANSFERASE | - |
dc.subject.keywordAuthor | SULFURIC ACID ESTERS | - |
dc.subject.keywordAuthor | BENZYLIC ALCOHOLS | - |
dc.subject.keywordAuthor | CARCINOGENESIS AND MUTAGENESIS | - |
dc.subject.keywordAuthor | POLYCYCLIC AROMATIC HYDROCARBONS | - |
dc.subject.keywordAuthor | DNA ADDUCTS | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.