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Dual roles of pin1 in cancer development and progression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Hyeong-Jun | - |
dc.contributor.author | Choi, Bu Young | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:26:58Z | - |
dc.date.available | 2021-01-31T09:26:58Z | - |
dc.date.created | 2018-11-15 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Current Pharmaceutical Design, Vol.23 No.29, pp.4422-4425 | - |
dc.identifier.issn | 1381-6128 | - |
dc.identifier.other | 68936 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172685 | - |
dc.description.abstract | Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary. | - |
dc.language | 영어 | - |
dc.publisher | Bentham Science Publishers | - |
dc.title | Dual roles of pin1 in cancer development and progression | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.2174/1381612823666170703164711 | - |
dc.citation.journaltitle | Current Pharmaceutical Design | - |
dc.identifier.wosid | 000415378600016 | - |
dc.identifier.scopusid | 2-s2.0-85038818183 | - |
dc.citation.endpage | 4425 | - |
dc.citation.number | 29 | - |
dc.citation.startpage | 4422 | - |
dc.citation.volume | 23 | - |
dc.identifier.sci | 000415378600016 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROLYL-ISOMERASE PIN1 | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | NUCLEAR TRANSLOCATION | - |
dc.subject.keywordPlus | CYCLIN-E | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MITOSIS | - |
dc.subject.keywordPlus | UBIQUITINATION | - |
dc.subject.keywordAuthor | Pin1 | - |
dc.subject.keywordAuthor | proline-directed protein kinases | - |
dc.subject.keywordAuthor | phosphorylation-dependent peptidyl-prolyl isomerase | - |
dc.subject.keywordAuthor | pSer/Thr-Pro motif | - |
dc.subject.keywordAuthor | PPIase | - |
dc.subject.keywordAuthor | proline isomerization | - |
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