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Chemopreventive and therapeutic potential of phytochemicals targeting cancer stem cells

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Authors
Kim, Do-Hee; Surh, Young-Joon
Issue Date
2015-10
Citation
Current Pharmacology Reports, Vol.1 No.5, pp.302-311
Keywords
Cancer stem cellsCell surface markersCellular signalingDietary phytochemicalsEpithelial mesenchymal transitionSelf-renewal
Abstract
Cancer stem cells (CSCs) constitute a subpopulation of transformed cells that possess intrinsic ability to undergo self-renewal and differentiation, which confers resistance to conventional anti-cancer therapy and cancer recurrence. The development of more effective cancer therapies hence requires identification of target subpopulations with distinct CSC phenotypes. Therefore, targeting CSCs is now considered as a rational and fundamental approach in the management of cancer. Components of signaling network involved in maintaining stemness of some CSCs and their self-renewal capability have been recently discovered. Some edible phytochemicals modulate signal transduction involved in self-renewal and survival of CSCs, thereby improving the efficacy of the current anti-cancer strategies. This article deals with chemopreventive/chemotherapeutic potential of selected phytochemicals, such as genistein, sulforaphane, curcumin, and epigallocatechin gallate in the context of their modulation of signal transduction networking among components of CSCs. © 2015, Springer International Publishing AG.
ISSN
2198-641X
URI
https://hdl.handle.net/10371/172687
DOI
https://doi.org/10.1007/s40495-015-0035-9
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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