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The strong hepatocarcinogenicity of the electrophilic and mutagenic metabolite 6-sulfooxymethylbenzo[α]pyrene and its formation of benzylic dna adducts in the livers of infant male B6C3F1 mice
DC Field | Value | Language |
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dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Liem, Amy | - |
dc.contributor.author | Miller, Elizabeth C. | - |
dc.contributor.author | Miller, James A. | - |
dc.date.accessioned | 2021-01-31T09:27:16Z | - |
dc.date.available | 2021-01-31T09:27:16Z | - |
dc.date.created | 2019-10-18 | - |
dc.date.issued | 1990-10 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.172 No.1, pp.85-91 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 85285 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172690 | - |
dc.description.abstract | 6-Hydroxymethylbenzo[α]pyrene was activated to an electrophilic and mutagenic sulfuric acid ester metabolite by rat and mouse liver sulfotransferase activity. The intrinsic mutagenicity of this reactive ester, 6-sulfooxymethylbenzo[α]pyrene, was inhibited by glutathione and glutathione S-transferase. A single i.p. dose of 2.5 nmol/g body wt of 6-sulfooxymethylbenzo[α]pyrene in infant male B6C3F1 mice induced liver tumors in 35 of 36 mice at 10 months with an average multiplicity of 4.4. A comparable dose of the parent hydrocarbon, 6-hydroxymethylbenzo[α]pyrene, was only a tenth as active. The electrophilic sulfuric acid ester produced high levels of benzylic DNA adducts in the livers of these mice that accounted for about 80% of the total DNA adducts. These results strongly suggest that this sulfuric acid ester is an important ultimate electrophilic and carcinogenic metabolite in carcinogenesis by 6-hydroxymethylbenzo[α]pyrene and possibly even by 6-methylbenzo[α]pyrene and benzo[α]pyrene in mouse liver. © 1990 Academic Press, Inc. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | The strong hepatocarcinogenicity of the electrophilic and mutagenic metabolite 6-sulfooxymethylbenzo[α]pyrene and its formation of benzylic dna adducts in the livers of infant male B6C3F1 mice | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0006-291X(05)80176-7 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | A1990EC64600013 | - |
dc.identifier.scopusid | 2-s2.0-0025147564 | - |
dc.citation.endpage | 91 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 85 | - |
dc.citation.volume | 172 | - |
dc.identifier.sci | A1990EC64600013 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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