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NF-κB and AP-1 as molecular targets for chemoprevention with EGCG, a review

Cited 13 time in Web of Science Cited 16 time in Scopus
Authors
Surh, Young-Joon
Issue Date
2006-08
Citation
Environmental Chemistry Letters, Vol.4 No.3, pp.137-141
Keywords
chemopreventionEGCGgreen teasignal transductionNF-kappaBAP-1
Abstract
There are multiple lines of compelling evidence, mostly from population-based studies, supporting that green tea consumption is associated with reduced risk of several human malignancies. Epigallocatechin gallate (EGCG) is a major antioxidant present in green tea. Chemopreventive effects of EGCG have been extensively investigated and well documented. These include inhibition of metabolic activation of carcinogens and/or stimulation of their detoxification, scavenging of reactive oxygen species, induction of apoptosis or differentiation of malignant or transformed cells, suppression of tumor promotion, inhibition of angiogenesis or metastasis, etc. EGCG targets many intracellular signaling molecules and events responsible for malignant transformation or abnormal cell proliferation, and NF-kappa B and AP-1 appear to be two of most potential targets of EGCG in its exerting chemopreventive activities.
ISSN
1610-3653
URI
https://hdl.handle.net/10371/172692
DOI
https://doi.org/10.1007/s10311-006-0063-0
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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