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Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: A short review
DC Field | Value | Language |
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dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:27:56Z | - |
dc.date.available | 2021-01-31T09:27:56Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2002-08 | - |
dc.identifier.citation | Food and Chemical Toxicology, Vol.40 No.8, pp.1091-1097 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.other | 4626 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172700 | - |
dc.description.abstract | A wide variety of phenolic substances derived from spice possess potent antimutagenic and anticarcinogenic activities. Examples are curcumin, a yellow colouring agent, contained in turmeric (Curcuma longs L., Zingiberaceae), [6]-gingerol, a pungent ingredient present in ginger (Zingiber officinale Roscoe, Zingiberaceae) and capsaicin, a principal pungent principle of hot chili pepper (Capsicum annuum L, Solanaceae). The chemopreventive effects exerted by these phytochemicals are often associated with their antioxidative and anti-inflammatory activities. Cyclo-oxygenase-2 (COX-2) has been recognized as a molecular target of many chemopreventive as well as anti-inflammatory agents. Recent studies have shown that COX-2 is regulated by the eukaryotic transcription factor NF-kappaB. This short review summarizes the molecular mechanisms underlying chemopreventive effects of the aforementioned spice ingredients in terms of their effects on intracellular signaling cascades, particularly those involving NF-kappaB and mitogen-activated protein kinases. (C) 2002 Elsevier Science Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: A short review | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0278-6915(02)00037-6 | - |
dc.citation.journaltitle | Food and Chemical Toxicology | - |
dc.identifier.wosid | 000177393700007 | - |
dc.identifier.scopusid | 2-s2.0-0036279287 | - |
dc.citation.endpage | 1097 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1091 | - |
dc.citation.volume | 40 | - |
dc.identifier.sci | 000177393700007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ORNITHINE DECARBOXYLASE ACTIVITY | - |
dc.subject.keywordPlus | MOUSE SKIN CARCINOGENESIS | - |
dc.subject.keywordPlus | ESTER-INDUCED ACTIVATION | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | MOLECULAR MECHANISMS | - |
dc.subject.keywordPlus | INDUCED EXPRESSION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordAuthor | spice | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordAuthor | curcumin | - |
dc.subject.keywordAuthor | gingerol | - |
dc.subject.keywordAuthor | capsaicin | - |
dc.subject.keywordAuthor | intracellular signaling cascades | - |
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