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Janus-faced role of SIRT1 in tumorigenesis

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dc.contributor.authorSong, Na-Young-
dc.contributor.authorSurh, Young-Joon-
dc.date.accessioned2021-01-31T09:28:17Z-
dc.date.available2021-01-31T09:28:17Z-
dc.date.created2017-11-15-
dc.date.created2017-11-15-
dc.date.issued2012-10-
dc.identifier.citationAnnals of the New York Academy of Sciences, Vol.1271, pp.10-19-
dc.identifier.issn0077-8923-
dc.identifier.other2102-
dc.identifier.urihttps://hdl.handle.net/10371/172705-
dc.description.abstractSilent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins. Notably, cumulative evidence supports the notion that SIRT1 has a Janus-faced role in tumorigenesis. SIRT1 contributes to anti-inflammation, genomic stability, and cancer cell death, and hence it has tumor-suppressor properties. On the other hand, SIRT1 can stimulate oncogenic signaling pathways and can create a tumor microenvironment favorable to growth and survival of cancer cells. Such dual functions of SIRT1 may be determined, at least in part, by its subcellular localization. Interestingly, SIRT1 displays differential localization in normal cells and cancer cells, which in turn may affect the substrate specificity for its deacetylase activity.-
dc.language영어-
dc.publisherNew York Academy of Sciences-
dc.titleJanus-faced role of SIRT1 in tumorigenesis-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1111/j.1749-6632.2012.06762.x-
dc.citation.journaltitleAnnals of the New York Academy of Sciences-
dc.identifier.wosid000312488700002-
dc.identifier.scopusid2-s2.0-84867380741-
dc.citation.endpage19-
dc.citation.startpage10-
dc.citation.volume1271-
dc.identifier.sci000312488700002-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
dc.type.docTypeArticle; Proceedings Paper-
dc.description.journalClass1-
dc.subject.keywordPlusPROTEIN DEACETYLASE SIRT1-
dc.subject.keywordPlusPROMOTES CELL-SURVIVAL-
dc.subject.keywordPlusHUMAN CANCER-CELLS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusREGULATES SIRT1-
dc.subject.keywordPlusTELOMERE MAINTENANCE-
dc.subject.keywordPlusHISTONE DEACETYLASE-
dc.subject.keywordPlusNEGATIVE REGULATOR-
dc.subject.keywordPlusPROSTATE-CANCER-
dc.subject.keywordPlusDOWN-REGULATION-
dc.subject.keywordAuthorSIRT1-
dc.subject.keywordAuthorcancer-
dc.subject.keywordAuthorsubcellular localization-
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