Publications
Detailed Information
Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-kappa B and STAT3 as potential targets
Cited 41 time in
Web of Science
Cited 47 time in Scopus
- Authors
- Issue Date
- 2013-07
- Publisher
- Academic Press
- Citation
- Biochemical and Biophysical Research Communications, Vol.437 No.2, pp.267-273
- Abstract
- Diallyl trisulfide (DATS), one of the volatile constituents of garlic oil, has been reported to possess antioxidant, anti-inflammatory, and anti-carcinogenic properties. In this study, DATS (10 mu mop given orally for 7 days before and for another 7 days after starting administration of 2.5% dextran sulfate sodium (DSS) in drinking water protected against colitis induced by DSS in male ICR mice. DATS significantly inhibited the DSS-induced DNA binding of NF-kappa B, phosphorylation of I kappa B alpha and the expression of pro-inflammatory proteins, such as cyclooxygenase-2 and inducible nitric oxide synthase, which are major target proteins of NF-kappa B. The DSS-induced DNA binding and phosphorylation at the Tyr 705 residue of signal transducer and activator of transcription 3 (STAT3), and expression of its major target protein cyclin D1 in mouse colonic mucosa were also attenuated by DATS administration. Likewise, DSS-induced phosphorylation of extracellular signal-regulated kinase 1/2 was suppressed by DATS treatment. In conclusion, DATS ameliorates the DSS-induced mouse colitis presumably by blocking inflammatory signaling mediated by NF-kappa B and STAT3. (C) 2013 Elsevier Inc. All rights reserved.
- ISSN
- 0006-291X
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.