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Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-kappa B and STAT3 as potential targets

Cited 34 time in Web of Science Cited 38 time in Scopus
Authors
Lee, Hyung-Jun; Lee, Hee Geum; Choi, Ki-Seok; Surh, Young-Joon; Na, Hye-Kyung
Issue Date
2013-07
Citation
Biochemical and Biophysical Research Communications, Vol.437 No.2, pp.267-273
Keywords
Diallyl trisulfideNE-kappa BSTAT3Mouse colitis
Abstract
Diallyl trisulfide (DATS), one of the volatile constituents of garlic oil, has been reported to possess antioxidant, anti-inflammatory, and anti-carcinogenic properties. In this study, DATS (10 mu mop given orally for 7 days before and for another 7 days after starting administration of 2.5% dextran sulfate sodium (DSS) in drinking water protected against colitis induced by DSS in male ICR mice. DATS significantly inhibited the DSS-induced DNA binding of NF-kappa B, phosphorylation of I kappa B alpha and the expression of pro-inflammatory proteins, such as cyclooxygenase-2 and inducible nitric oxide synthase, which are major target proteins of NF-kappa B. The DSS-induced DNA binding and phosphorylation at the Tyr 705 residue of signal transducer and activator of transcription 3 (STAT3), and expression of its major target protein cyclin D1 in mouse colonic mucosa were also attenuated by DATS administration. Likewise, DSS-induced phosphorylation of extracellular signal-regulated kinase 1/2 was suppressed by DATS treatment. In conclusion, DATS ameliorates the DSS-induced mouse colitis presumably by blocking inflammatory signaling mediated by NF-kappa B and STAT3. (C) 2013 Elsevier Inc. All rights reserved.
ISSN
0006-291X
URI
https://hdl.handle.net/10371/172714
DOI
https://doi.org/10.1016/j.bbrc.2013.06.064
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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