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β-Amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-κB signaling pathway : beta-Amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappa B signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Jang, Jung-Hee | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:28:56Z | - |
dc.date.available | 2021-01-31T09:28:56Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2005-06 | - |
dc.identifier.citation | Free Radical Biology and Medicine, Vol.38 No.12, pp.1604-1613 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.other | 3948 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172716 | - |
dc.description.abstract | Inflammatory cell death as well as oxidative stress has been implicated in some neurodegenerative disorders such as Alzheimer's disease (AD). Expression of cyclooxygenase-2 (COX-2) and production of prostaglandins have been frequently elevated in AD. In this study, we have investigated the molecular mechanisms underlying inflammatory cell death induced by beta-amyloid (A beta), a neurotoxic peptide that accumulates in senile plaques formed in the brains of AD patients. Rat pheochromocytoma (PC12) cells treated with A beta exhibited increased mRNA and protein expression of COX-2 and production of prostaglandin E-2 (PGE(2)) and underwent apoptotic death as determined by positive in situ terminal end-labeling, decreased mitochondrial membrane potential, increased Bax/Bcl-X-L ratio, activation of c-Jun N-terminal kinase, and cleavage of poly(ADP-ribose)polymerase. Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated A beta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2). A beta transiently induced activation of redox-sensitive transcription factor NF-kappa B, and pretreatment of PC12 cells with NF-kappa B inhibitors abolished the A beta-induced COX-2 expression. Pharmacologic inhibition of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38 MAPK) and dominant-negative mutation of both enzymes suppressed not only A beta-induced NF-kappa B transactivation but also COX-2 expression and PGE(2) production. The above findings suggest that A beta-induced apoptosis in PC12 cells is associated with COX-2 up-regulation through activation of NF-kappa B, which is mediated by upstream kinases including ERK and p38 MAPK. (c) 2005 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | β-Amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-κB signaling pathway | - |
dc.title.alternative | beta-Amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappa B signaling pathway | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2005.02.023 | - |
dc.citation.journaltitle | Free Radical Biology and Medicine | - |
dc.identifier.wosid | 000229666100007 | - |
dc.identifier.scopusid | 2-s2.0-19444377638 | - |
dc.citation.endpage | 1613 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 1604 | - |
dc.citation.volume | 38 | - |
dc.identifier.sci | 000229666100007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | HIPPOCAMPAL-FORMATION | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | inflammatory cell death | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | p38 MAPK | - |
dc.subject.keywordAuthor | PC12 cells | - |
dc.subject.keywordAuthor | oxidative stress | - |
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