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Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1

Cited 130 time in Web of Science Cited 136 time in Scopus
Authors
Na, Hye-Kyung; Surh, Young-Joon
Issue Date
2014-02
Citation
Free Radical Biology and Medicine, Vol.67, pp.353-365
Keywords
Redox balanceNrf2Heme oxygenase-1Adaptive survival responseChemoresistanceRadioresistanceAntioxidant response elementsFree radicals
Abstract
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular defense against a vast variety of endogenous and exogenous insults, including oxidative stress. Nrf2 acts as a master switch in the circuits upregulating the expression of various stress-response proteins, especially heme oxygenase-1 (HO-1). Paradoxically, however, recent studies have demonstrated oncogenic functions of Nrf2 and its major target protein HO-1. Levels of Nrf2 and HO-1 are elevated in many different types of human malignancies, which may facilitate the remodeling of the tumor microenvironment making it advantageous for the autonomic growth of cancer cells, metastasis, angiogenesis, and tolerance to chemotherapeutic agents and radiation and photodynamic therapy. In this context, the cellular stress response or cytoprotective signaling mediated via the Nrf2-HO-1 axis is hijacked by cancer cells for their growth advantage and survival of anticancer treatment. Therefore, Nrf2 and HO-1 may represent potential therapeutic targets in the management of cancer. This review highlights the roles of Nrf2 and HO-1 in proliferation of cancer cells, their tolerance/resistance to anticancer treatments, and metastasis or angiogenesis in tumor progression. (C) 2013 Elsevier Inc. All rights reserved.
ISSN
0891-5849
URI
https://hdl.handle.net/10371/172723
DOI
https://doi.org/10.1016/j.freeradbiomed.2013.10.819
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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