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ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Inoue, Hiroyasu | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:13:50Z | - |
dc.date.available | 2021-01-31T10:13:50Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2005-11 | - |
dc.identifier.citation | FEBS Letters, Vol.579 No.27, pp.6279-6287 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.other | 3865 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172743 | - |
dc.description.abstract | Abnormally elevated expression of cyclooxygenase-2 (COX-2) has been frequently observed in transformed or malignant cells, and certain non-steroidal anti-inflammatory drugs with COX-2 inhibitory activity exert anti-neoplastic or chemopreventive effects. Contrary to this notion, we have found that a novel alkylphospholipid type antitumor agent ET-18-O-CH3 (1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine) induces COX-2 expression in H-ras transformed human breast epithelial cells (MCF10A-ras) while it causes apoptosis at the same concentration range. The addition of a selective COX-2 inhibitor SC-58635 and COX-2 gene knock down with the siRNA blocked ET-18-O-CH3-induced apoptosis, suggesting that COX-2 induction by this drug is causally linked to its apoptosis inducing activity. ET-18-O-CH3 enhanced the transcriptional activities of cyclic AMP response element which is a key regulator of COX-2 expression. 15-Deoxy-Delta-(12,14) prostaglandin J(2) is, an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma), has been known to possess proapoptotic potential in diverse cell types. ET-18-O-CH3 treatment resulted in elevated release of 15d-PGJ(2) and DNA binding and transcriptional activity of PPAR gamma. Based on these findings, it is likely that ET-18-O-CH3 induces COX-2 expression and production of 15d-PGJ2 which may mediate the ET-18-O-CH3-induced apoptosis in MCF10A-ras cells. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.febslet.2005.09.094 | - |
dc.citation.journaltitle | FEBS Letters | - |
dc.identifier.wosid | 000233157800045 | - |
dc.identifier.scopusid | 2-s2.0-27544490730 | - |
dc.citation.endpage | 6287 | - |
dc.citation.number | 27 | - |
dc.citation.startpage | 6279 | - |
dc.citation.volume | 579 | - |
dc.identifier.sci | 000233157800045 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | PROLIFERATOR-ACTIVATED RECEPTORS | - |
dc.subject.keywordPlus | HUMAN HEPATIC MYOFIBROBLASTS | - |
dc.subject.keywordPlus | VASCULAR ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | HUMAN LEUKEMIC-CELLS | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | PHORBOL ESTER | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INDUCE APOPTOSIS | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | ET-18-O-CH3 | - |
dc.subject.keywordAuthor | 15-deoxy-triangle(12,14)-prostaglandin J(2) | - |
dc.subject.keywordAuthor | human breast epithelial cells transformed with H-ras (MCF10A-ras) | - |
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