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Resveratrol suppresses 4-hydroxyestradiol-induced transformation of human breast epithelial cells by blocking I kappa B kinase beta-NF-kappa B signalling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sin-Aye | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:13:53Z | - |
dc.date.available | 2021-01-31T10:13:53Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Free Radical Research, Vol.46 No.8, pp.1051-1057 | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.other | 1934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172744 | - |
dc.description.abstract | Excess estrogen stimulates the proliferation of mammary epithelial cells and hence represents a major risk factor for breast cancer. Estrogen is subjected to cytochrome P450-catalysed oxidative metabolism to produce an oncogenic catechol estrogen, 4-hydroxyestradiol (4-OHE2). 4-OHE2 undergoes redox cycling during which reactive oxygen species (ROS) as well as the chemically reactive estrogen semiquinone and quinone intermediates are produced, thereby contributing to hormonal carcinogenesis. Resveratrol (3,4',5-trihydroxy stilbene), a phytoalexin present in grapes, has been reported to possess chemopreventive and chemotherapeutic activities. In the present study, we examined the inhibitory effects of resveratrol on 4-OHE2-induced transformation of human breast epithelial MCF-10A cells. Resveratrol inhibited migration and anchorage-independent growth of MCF-10A cells treated with 4-OHE2. Resveratrol treatment suppressed the 4-OHE2-induced activation of I kappa B kinase beta (IKK beta) and phosphorylation of I kappa B alpha, and consequently NF-kappa B DNA binding activity and cyclooxygenase-2 (COX-2) expression. Resveratrol suppressed ROS production and phosphorylation of Akt and ERK induced by 4-OHE2 treatment. In conclusion, resveratrol blocks activation of IKK beta-NF-kappa B signalling and induction of COX-2 expression in 4-OHE2-treated MCF-10A cells, thereby suppressing migration and transformation of these cells. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | Resveratrol suppresses 4-hydroxyestradiol-induced transformation of human breast epithelial cells by blocking I kappa B kinase beta-NF-kappa B signalling | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.3109/10715762.2012.671940 | - |
dc.citation.journaltitle | Free Radical Research | - |
dc.identifier.wosid | 000306427200013 | - |
dc.identifier.scopusid | 2-s2.0-84863890576 | - |
dc.citation.endpage | 1057 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1051 | - |
dc.citation.volume | 46 | - |
dc.identifier.sci | 000306427200013 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | ESTROGEN METABOLISM | - |
dc.subject.keywordPlus | CATECHOL ESTROGENS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ADDUCT FORMATION | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordAuthor | resveratrol | - |
dc.subject.keywordAuthor | 4-hydroxyestradiol | - |
dc.subject.keywordAuthor | catechol estrogen | - |
dc.subject.keywordAuthor | I kappa B kinase beta | - |
dc.subject.keywordAuthor | human mammary epithelial cells | - |
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