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15-Deoxy-Delta(12,14)-prostaglandin J(2) induces p53 expression through Nrf2-mediated upregulation of heme oxygenase-1 in human breast cancer cells : 15-Deoxy-Δ12,14-prostaglandin J2 induces p53 expression through Nrf2-mediated upregulation of heme oxygenase-1 in human breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, D. H. | - |
dc.contributor.author | Song, N. Y. | - |
dc.contributor.author | Kim, E. H. | - |
dc.contributor.author | Na, H. K. | - |
dc.contributor.author | Joe, Y. | - |
dc.contributor.author | Chung, H. T. | - |
dc.contributor.author | Surh, Y. J. | - |
dc.date.accessioned | 2021-01-31T10:13:56Z | - |
dc.date.available | 2021-01-31T10:13:56Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | Free Radical Research, Vol.48 No.9, pp.1018-1027 | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.other | 1244 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172745 | - |
dc.description.abstract | Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that has antioxidant and cytoprotective functions. However, HO-1 has oncogenic functions in cancerous or transformed cells. In the present work, we investigated the effects of HO-1 on the expression of p53 induced by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) in human breast cancer (MCF-7) cells. Treatment of MCF-7 cells with 15d-PGJ(2) led to time-dependent increases in the expression of p53 as well as HO-1. Upregulation of p53 expression by 15d-PGJ2 was abrogated by si-RNA knock-down of HO-1. In MCF-7 cells transfected with HO-1 si-RNA, 15d-PGJ(2) failed to induce expression of p53 as well as HO-1. In addition, HO-1 inducers enhanced the p53 expression. We speculated that iron, a by-product of HO-1-catalyzed reactions, could mediate 15d-PGJ(2)-induced p53 expression. Upregulation of p53 expression by 15d-PGJ(2) was abrogated by the iron chelator desferrioxamine in MCF-7 cells. Iron released from heme by HO-1 activity is mostly in the Fe2+ form. When MCF-7 cells were treated with the Fe2+-specific chelator phenanthroline, 15d-PGJ(2)-induced p53 expression was attenuated. In addition, levels of the Fe-sequestering protein H-ferritin were elevated in 15d-PGJ(2)-treated MCF-7 cells. In conclusion, upregulation of p53 and p21 via HO-1 induction and subsequent release of iron with accumulation of H-ferritin may confer resistance to oxidative damage in cancer cells frequently challenged by redox-cycling anticancer drugs. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces p53 expression through Nrf2-mediated upregulation of heme oxygenase-1 in human breast cancer cells | - |
dc.title.alternative | 15-Deoxy-Δ12,14-prostaglandin J2 induces p53 expression through Nrf2-mediated upregulation of heme oxygenase-1 in human breast cancer cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.3109/10715762.2014.897343 | - |
dc.citation.journaltitle | Free Radical Research | - |
dc.identifier.wosid | 000340456000006 | - |
dc.identifier.scopusid | 2-s2.0-84906053071 | - |
dc.citation.endpage | 1027 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 1018 | - |
dc.citation.volume | 48 | - |
dc.identifier.sci | 000340456000006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Y. J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CONFERS RESISTANCE | - |
dc.subject.keywordPlus | IRON HOMEOSTASIS | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | FERRITIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | 15-Deoxy-Delta(12,14)-prostaglandin J(2) | - |
dc.subject.keywordAuthor | Heme oxygenase-1 | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | H-ferritin | - |
dc.subject.keywordAuthor | Cyclopentenone prostaglandin | - |
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