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[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin-Kyoung | - |
dc.contributor.author | Kim, Younghwa | - |
dc.contributor.author | Na, Kwang-Min | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Kim, Tae-Yoon | - |
dc.date.accessioned | 2021-01-31T10:14:08Z | - |
dc.date.available | 2021-01-31T10:14:08Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Free Radical Research, Vol.41 No.5, pp.603-614 | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.other | 3558 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172748 | - |
dc.description.abstract | [6]-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger (Zingiber officinale Roscoe, Zingiberaceae) and has diverse pharmacologic effects. Here, we describe its novel anti-oxidant, anti-apoptotic, and anti-inflammatory activities in vitro and in vivo. In vitro, pre-treatment with [6]-gingerol reduced UVB-induced intracellular reactive oxygen species levels, activation of caspase-3, -8, -9, and Fas expression. It also reduced UVB-induced expression and transactivation of COX-2. Translocation of NF-kappa B from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of I kappa B alpha phosphorylation (ser-32). Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 mM) prior to UVB irradiation (5 kJ/m(2)) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-kappa B translocation. These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1080/10715760701209896 | - |
dc.citation.journaltitle | Free Radical Research | - |
dc.identifier.wosid | 000245589100011 | - |
dc.identifier.scopusid | 2-s2.0-34047135039 | - |
dc.citation.endpage | 614 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 603 | - |
dc.citation.volume | 41 | - |
dc.identifier.sci | 000245589100011 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ESTER-INDUCED EXPRESSION | - |
dc.subject.keywordPlus | HUMAN SKIN FIBROBLASTS | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | MOUSE SKIN | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | ORNITHINE-DECARBOXYLASE | - |
dc.subject.keywordAuthor | UVB | - |
dc.subject.keywordAuthor | [6]-gingerol | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | caspase | - |
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