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Perilla frutescens extracts protects against dextran sulfate sodium-induced murine colitis: NF-κB, STAT3, and Nrf2 as putative targets : Perilla frutescens Extracts Protects against Dextran Sulfate Sodium-Induced Murine Colitis: NF-kappa B, STAT3, and Nrf2 as Putative Targets
DC Field | Value | Language |
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dc.contributor.author | Park, Deung Dae | - |
dc.contributor.author | Yum, Hye-Won | - |
dc.contributor.author | Zhong, Xiancai | - |
dc.contributor.author | Kim, Seung Hyeon | - |
dc.contributor.author | Kim, Seong Hoon | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Sato, Atsuya | - |
dc.contributor.author | Miura, Takehito | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:14:15Z | - |
dc.date.available | 2021-01-31T10:14:15Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Frontiers in Pharmacology, Vol.8, p. 482 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.other | 234 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172749 | - |
dc.description.abstract | Perilla frutescens is a culinary and medicinal herb which has a strong anti-inflammatory and antioxidative effects. In the present study, we investigated the effects of Perilla frutescens extract (PE) against dextran sulfate sodium (DSS)-induced mouse colitis, an animal model that mimics human inflammatory bowel disease (IBD). Five-week-old male ICR mice were treated with a daily dose of PE (20 or 100 mg/kg, p.o.) for 1 week, followed by administration of 3% DSS in double distilled drinking water and PE by gavage for another week. DSS-induced colitis was characterized by body weight loss, colon length shortening, diarrhea and bloody stool, and these symptoms were significantly ameliorated by PE treatment. PE administration suppressed DSS-induced expression of proinflammatory enzymes, including cyclooxygenase-2 and inducible nitric oxide synthase as well as cyclin D1; in a dose-dependent fashion. Nuclear factor-kappa B (NF-kappa B) and signal transducer and activator of transcription 3 (STAT3) are major transcriptional regulators of inflammatory signaling. PE administration significantly inhibited the activation of both NF-kappa B and STAT3 induced by DSS, while it elevated the accumulation of Nrf2 and heme oxygenase-1 in the colon. In another experiment, treatment of CCD841CoN human normal colon epithelial cells with PE (10 mg/ml) resulted in the attenuation of the tumor necrosis factor-alpha-induced expression/activation of mediators of proinflammatory signaling. The above results indicate that PE has a preventive potential for use in the management of IBD. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Perilla frutescens extracts protects against dextran sulfate sodium-induced murine colitis: NF-κB, STAT3, and Nrf2 as putative targets | - |
dc.title.alternative | Perilla frutescens Extracts Protects against Dextran Sulfate Sodium-Induced Murine Colitis: NF-kappa B, STAT3, and Nrf2 as Putative Targets | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.3389/fphar.2017.00482 | - |
dc.citation.journaltitle | Frontiers in Pharmacology | - |
dc.identifier.wosid | 000407480400001 | - |
dc.identifier.scopusid | 2-s2.0-85027466999 | - |
dc.citation.startpage | 482 | - |
dc.citation.volume | 8 | - |
dc.identifier.sci | 000407480400001 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | DSS-INDUCED COLITIS | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCER | - |
dc.subject.keywordPlus | SUPPRESSOR-CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACTIVATOR | - |
dc.subject.keywordPlus | TRANSCRIPTION-3 | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | colitis | - |
dc.subject.keywordAuthor | dextran sulfate sodium | - |
dc.subject.keywordAuthor | inflammatory bowel disease | - |
dc.subject.keywordAuthor | Perilla frutescens | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | STAT3 | - |
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