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Epigallocatechin Gallate inhibits phorbol ester-induced activation of NF-κB and CREB in mouse skin role of p38 MAPK : Epigallocatechin Gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin - Role of p38 MAPK
DC Field | Value | Language |
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dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:15:00Z | - |
dc.date.available | 2021-01-31T10:15:00Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2007-01 | - |
dc.identifier.citation | Annals of the New York Academy of Sciences, Vol.1095, pp.504-512 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.other | 3590 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172757 | - |
dc.description.abstract | The modulation of intracellular signaling network involved in an inappropriate expression of cyclooxygenase-2- (COX-2) is a pragmatic approach for chemoprevention with a wide variety of dietary phytochemicals. Epigallocatechin gallate (EGCG), a major green tea polyphenol, is one of the most extensively investigated chemopreventive agents. Our previous study revealed that EGCG inhibited expression of COX-2 and activation of mitogen-activated protein kinases (MAPKs) in mouse skin stimulated with a prototype tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA). This study was aimed at identifying transcription factors as molecular targets of EGCG in downregulating COX-2 expression. We found that EGCG inhibited TPA-induced DNA binding of NF-kappa B and CREB in mouse skin in vivo. EGCG also suppressed TPA-induced phosphorylation and subsequent degradation of I kappa B alpha, and prevented nuclear translocation of p65. We also examined whether extracellular signal-regulated protein kinase (ERK) and p38 MAPK, which are known to regulate activation of NF-kappa B, can also modulate CREB DNA binding. Pretreatment with U0126 and SB203580, pharmacological inhibitors of ERK and p38 MAPK, respectively, showed that SB203580, but not U0126, attenuated TPA-induced CREB DNA binding in mouse skin. Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappa B and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo. | - |
dc.language | 영어 | - |
dc.publisher | New York Academy of Sciences | - |
dc.title | Epigallocatechin Gallate inhibits phorbol ester-induced activation of NF-κB and CREB in mouse skin role of p38 MAPK | - |
dc.title.alternative | Epigallocatechin Gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin - Role of p38 MAPK | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1196/annals.1397.054 | - |
dc.citation.journaltitle | Annals of the New York Academy of Sciences | - |
dc.identifier.wosid | 000245947400053 | - |
dc.identifier.scopusid | 2-s2.0-34247842801 | - |
dc.citation.endpage | 512 | - |
dc.citation.startpage | 504 | - |
dc.citation.volume | 1095 | - |
dc.identifier.sci | 000245947400053 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 GENE | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | (-)-EPIGALLOCATECHIN-3-GALLATE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | POLYPHENOL | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | epigallocatechin gallate | - |
dc.subject.keywordAuthor | mouse skin | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | CREB | - |
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