S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Inhibitory effects of 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone (DA-6034) on Helicobacter pylori-induced NF-κB activation and iNOS expression in AGS cells
- Lee, Jeong-Sang; Kim, Hyun-Soo; Hahm, Ki-Baik; Sohn, Mi-Won; Yoo, Moohi; Johnson, Jeffrey A.; Surh, Young-Joon
- Issue Date
- Annals of the New York Academy of Sciences, Vol.1095, pp.527-535
- Helicobacter pylori; proinflammatory response; ERK; I kappa B alpha p65; NF-kappa B; DA-6034
- The Helicobacter pylori were identified by Marshall and Warren in 1984. H. pylori survive in the forbidding harsh acid environment of the stomach and duodenum by hiding in the mucus layer and neutralizing gastric acid in its local surrounding environment. Multiple lines of evidence suggest that H. pylori infection is one of the primary causes of gastritis and peptic ulcer, which are provoked by oxidative stress and inflammation. More than 50% of the world's population is infected by this bacterium. The H. pylori-induced inflammation has been implicated in the pathogenesis and progression of gastric cancer. DA-6034 (7-carboxymethyloxy-3',4',5-trimethoxy flavone) is a synthetic flavonoid known to possess anti-inflammatory activity. It has been reported that oral administration of DA-6034 suppresses the inflammatory bowel disease (IBD) in animal models. In this article, we attempted to examine the effect of DA-6034 on H. pylori-induced inflammation in human gastric cancer (AGS) cells by targeting NF-kappa B and extracellular signal-regulated kinase (ERK), a representative MAPK.
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