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Attenuation of Aβ‐Induced Apoptosis of Plant Extract (Saengshik) Mediated by the Inhibition of Mitochondrial Dysfunction and Antioxidative Effect

Cited 7 time in Web of Science Cited 9 time in Scopus
Authors
Chen, Chu-Yue; Jang, Jung-Hee; Park, Mi Hyun; Hwang, Sung Joo; Surh, Young-Joon; Park, Ock Jin
Issue Date
2007-03
Citation
Annals of the New York Academy of Sciences, Vol.1095, pp.399-411
Keywords
Saengshikneuroprotective effectsantioxidant capacityPC12 cellsAlzheimer's disease
Abstract
Recently, considerable attention has been focused on dietary manipulation of oxidative and/or nitrosative damage on neuronal cells. In this article, a neuroprotective effect of plant (Saengshik) extracts was investigated. Rat pheochromocytoma (PC12), cells treated with beta-amyloid underwent apoptotic death as determined by positive in situ terminal end-labeling (TUNEL staining), decreased mitochondrial transmembrane potential, and elevated caspase-3 activity co-occurring with enhanced MDA accumulation and the reduction of GSH levels. Saengshik pretreatment attenuated beta-amyloid-induced apoptosis in PC12 cells possibly by inhibiting mitochondrial dysfunction and exerting antioxidant properties. Saengshik pretreatment inhibited the loss of mitochondrial membrane potentials and reduced the activation of caspase-3. The in vitro antioxidant activities of Saengshik extracts were verified by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and superoxide dismutase (SOD) mimetic activity. In beta-amyloid-challenged PC12 cells, Saengshik prevented the production of ROS, decreased the level of MDA, and elevated GSH. The potential of Saengshik as one of the neuroprotective regimens has been suggested through this article, and the combination with defined pharmaceuticals or other dietary antioxidants may provide a better therapeutic or preventive advantage for the management of Alzheimer's disease.
ISSN
0077-8923
URI
https://hdl.handle.net/10371/172759
DOI
https://doi.org/10.1196/annals.1397.043
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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