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Curcumin exerts antidifferentiation effect through AMPKα-PPAR-γ in 3T3-L1 adipocytes and antiproliferatory effect through AMPKα-COX-2 in cancer cells

Cited 134 time in Web of Science Cited 150 time in Scopus
Authors
Lee, Yun K.; Lee, Won S.; Hwang, Jin T.; Kwon, Dae Y.; Surh, Young-Joon; Park, Ock J.
Issue Date
2009-01
Citation
Journal of Agricultural and Food Chemistry, Vol.57 No.1, pp.305-310
Keywords
AMP-activated protein kinaseapoptosis of cancer cellscurcuminperoxisome proliferator-activated receptor-gammaadipocyte differentiation
Abstract
Curcumin has been reported to have the potential to prevent obesity as well as cancers. The downstream targets regulated by AMP-activated protein kinase (AMPK) for inhibiting adipocyte differentiation or cancer cell proliferation of curcumin were investigated. The activation of AMPK by curcumin was crucial for the inhibition of differentiation or growth in both adipocytes and cancer cells. Stimulation of AMPK by curcumin resulted in the down-regulation of PPAR (peroxisome proliferator-activated receptor)-gamma in 3T3-L1 adipocytes and the decrease in COX-2 in MCF-7 cells. Application of a synthetic AMPK activator also supported the evidence that AMPK acts as an upstream signal of PPAR-gamma in 3T3-L1 adipocytes. In cancer cells, AMPK was found to act as a regulator of ERK1/2, p38, and COX-2. Regulation of AMPK and its downstream targets such as PPAR-gamma, Mapkinases, and COX-2 by curcumin appears to be important in controlling adipocytes and cancerous cells.
ISSN
0021-8561
URI
https://hdl.handle.net/10371/172772
DOI
https://doi.org/10.1021/jf802737z
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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