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Curcumin suppresses activation of NF-κB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells

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Authors
Han, Seong-Su; Keum, Young-Sam; Seo, Hyo-Joung; Surh, Young-Joon
Issue Date
2002-05
Citation
Journal of Biochemistry and Molecular Biology, Vol.35 No.3, pp.337-342
Keywords
AP-1curcuminHL-60 cellsNF-kappa B12-O-tetradecanoylphorbol-13-acetate
Abstract
Many components that are derived from medicinal or dietary plants possess potential chemopreventive properties. Curcumin, a yellow coloring agent from turmeric (Curcuma longa Linn, Zingiberaceae), possesses strong antimutagenic and anticarcinogenic activities. In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kappaB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkappaBalpha and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells. Alternatively, curcumin repressed the TPA-induced activation of NF-kappaB through direct interruption of the binding of NF-kappaB to its consensus DNA sequences. Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment.
ISSN
0219-1024
URI
https://hdl.handle.net/10371/172775
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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