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APC inhibits ERK pathway activation and cellular proliferation induced by RAS
DC Field | Value | Language |
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dc.contributor.author | Park, Ki-Sook | - |
dc.contributor.author | Jeon, Soung Hoo | - |
dc.contributor.author | Kim, Sung-Eun | - |
dc.contributor.author | Bahk, Young-Yil | - |
dc.contributor.author | Holmen, Sheri L. | - |
dc.contributor.author | Williams, Bart O. | - |
dc.contributor.author | Chung, Kwang-Chul | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Choi, Kang-Yell | - |
dc.date.accessioned | 2021-01-31T10:16:43Z | - |
dc.date.available | 2021-01-31T10:16:43Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2006-03 | - |
dc.identifier.citation | Journal of Cell Science, Vol.119 No.5, pp.819-827 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.other | 3784 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172780 | - |
dc.description.abstract | Inactivating mutations in the adenomatous polyposis coli gene (APC), and activating mutations in RAS, occur in a majority of colorectal carcinomas. However, the relationship between these changes and tumorigenesis is poorly understood. RAS-induced activation of the ERK pathway was reduced by overexpressing APC in DLD-1 colorectal cancer cells. ERK activity was increased by Crevirus-induced Apc knockout in primary Apc(flow/flox) mouse embryonic fibroblasts, indicating that APC inhibits ERK activity. ERK activity was increased by overexpression and decreased by knock down of P-catenin. The activation of Raf1, MEK and ERK kinases by P-catenin was reduced by co-expression of APC. These results indicate that APC inhibits the ERK pathway by an action on P-catenin. RAS-induced activation of the ERK pathway was reduced by the dominant negative form of TCF4, indicating that the ERK pathway regulation by APC/beta-catenin signaling is, at least, partly caused by effects on beta-catenin/TCF4-mediated gene expression. The GTP loading and the protein level of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression, indicating that APC regulates RAS-induced ERK activation at least partly by reduction of the RAS protein level. APC regulates cellular proliferation and transformation induced by activation of both RAS and P-catenin signaling. | - |
dc.language | 영어 | - |
dc.publisher | The Company of Biologists Ltd. | - |
dc.title | APC inhibits ERK pathway activation and cellular proliferation induced by RAS | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1242/jcs.02779 | - |
dc.citation.journaltitle | Journal of Cell Science | - |
dc.identifier.wosid | 000236385300004 | - |
dc.identifier.scopusid | 2-s2.0-33645213204 | - |
dc.citation.endpage | 827 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 819 | - |
dc.citation.volume | 119 | - |
dc.identifier.sci | 000236385300004 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject.keywordPlus | COLORECTAL-CANCER CELLS | - |
dc.subject.keywordPlus | POLYPOSIS-COLI GENE | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | CADHERIN EXPRESSION | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | WNT PATHWAY | - |
dc.subject.keywordPlus | S-PHASE | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordAuthor | APC | - |
dc.subject.keywordAuthor | beta-catenin | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | RAS | - |
dc.subject.keywordAuthor | transformation | - |
dc.subject.keywordAuthor | Wnt | - |
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