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Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger
DC Field | Value | Language |
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dc.contributor.author | Surh, Young Joon | - |
dc.contributor.author | Park, Kwang-kyun | - |
dc.contributor.author | Chun, Kyung-soo | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Lee, Eunyong | - |
dc.contributor.author | Lee, Sang-sup | - |
dc.date.accessioned | 2021-01-31T10:16:55Z | - |
dc.date.available | 2021-01-31T10:16:55Z | - |
dc.date.created | 2019-10-21 | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Journal of Environmental Pathology, Toxicology and Oncology, Vol.18 No.2, pp.131-139 | - |
dc.identifier.issn | 0731-8898 | - |
dc.identifier.other | 85299 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172783 | - |
dc.description.abstract | Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been widely used as a dietary spice, as well as in traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, including [6]-gingerol and [6]paradol, and has been reported to possess a strong anti-inflammatory activity. These pungent substances have a vanilloid structure found in other chemopreventive phytochemicals, including curcumin. In our study, we found anti-tumor-promoting properties of [6]-gingerol and [6]-paradol. Thus, topical application of [6]-gingerol or [6]-paradol 30 min prior to 12-O- tetradecanoylphorbol-13-acetate (TPA) attenuated the skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene in female ICR mice. These substances also significantly inhibited the tumor-promoter-stimulated inflammation, TNF-α production, and activation of epidermal ornithine decarboxylase in mice. In another study, [6]-gingerol and [6]-paradol suppressed the superoxide production stimulated by TPA in differentiated HL- 60 cells. Taken together, these findings suggest that pungent vanilloids found in ginger possess potential chemopreventive activities. | - |
dc.language | 영어 | - |
dc.publisher | Begell House | - |
dc.title | Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.citation.journaltitle | Journal of Environmental Pathology, Toxicology and Oncology | - |
dc.identifier.scopusid | 2-s2.0-0033041930 | - |
dc.citation.endpage | 139 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 131 | - |
dc.citation.volume | 18 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young Joon | - |
dc.contributor.affiliatedAuthor | Lee, Sang-sup | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | [6]- paradol | - |
dc.subject.keywordAuthor | [6]-gingerol | - |
dc.subject.keywordAuthor | Antiinflammation | - |
dc.subject.keywordAuthor | Antitumor promotion | - |
dc.subject.keywordAuthor | Chemoprevention | - |
dc.subject.keywordAuthor | Ginger | - |
dc.subject.keywordAuthor | Mouse skin carcinogenesis | - |
dc.subject.keywordAuthor | Ornithine decarboxylase activity | - |
dc.subject.keywordAuthor | Vanilloids | - |
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