Publications
Detailed Information
Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Oh, Tae Young | - |
dc.contributor.author | Shin, Chang-Yell | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:16:58Z | - |
dc.date.available | 2021-01-31T10:16:58Z | - |
dc.date.created | 2017-11-16 | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Environmental Pathology, Toxicology and Oncology, Vol.24 No.4, pp.251-259 | - |
dc.identifier.issn | 0731-8898 | - |
dc.identifier.other | 6288 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172784 | - |
dc.description.abstract | Artemisia asiatica Nakai has been used frequently in traditional Asian medicine for the treatment of inflammation and cancer. Eupatilin (5,7-dihydroxy-3',4', 6-trimethoxy-flavone) was shown to be a pharmacologically active ingredient of A asiatica. In the present study, we found that expression of cyclin D1, a key protein that regulates G(1)/S progression, was decreased in MCF-10A-ras cells treated with eupatilin. Downregulation of cyclin D1 expression by eupatifin was accompanied by a reduced expression of c-Jun and the DNA binding activity of the transcription factor AP-1. The expression of p21(waf1/Cip1) was also decreased by eupatilin treatment in both protein and the mRNA levels. We concluded that the inhibitory effect of eupatilin on p21(waf1/Cip1) expression is likely to be associated with the downregulation of cyclin D1 expression and AP-1 activation, which play an important role in the cell cycle arrest of ras-transformed breast epithelial cells. | - |
dc.language | 영어 | - |
dc.publisher | Begell House | - |
dc.title | Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1615/JEnvironPatholToxicolOncol.v24.i4.20 | - |
dc.citation.journaltitle | Journal of Environmental Pathology, Toxicology and Oncology | - |
dc.identifier.wosid | 000234089300002 | - |
dc.identifier.scopusid | 2-s2.0-33644835136 | - |
dc.citation.endpage | 259 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 251 | - |
dc.citation.volume | 24 | - |
dc.identifier.sci | 000234089300002 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | CYCLE PROGRESSION | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | ARTEMISIA PLANTS | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | P21 GENE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordAuthor | Artemisia asiatica | - |
dc.subject.keywordAuthor | eupatilin | - |
dc.subject.keywordAuthor | MCF-10A-ras cells | - |
dc.subject.keywordAuthor | cell proliferation | - |
dc.subject.keywordAuthor | cell cycle arrest | - |
dc.subject.keywordAuthor | cyclin D1 | - |
dc.subject.keywordAuthor | AP-1 | - |
dc.subject.keywordAuthor | c-Jun | - |
dc.subject.keywordAuthor | p21(waf1/Cip1) | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.