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Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells

Cited 47 time in Web of Science Cited 50 time in Scopus
Authors
Kim, Min-Jung; Kim, Do-Hee; Na, Hye-Kyung; Oh, Tae Young; Shin, Chang-Yell; Surh, Young-Joon
Issue Date
2005
Citation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24 No.4, pp.261-269
Keywords
eupatilinArtemisia asiaticacell proliferationapoptosiscaspasecell cyclecell survivalcell deathgastric cancerchemopreventionAGS cellsapoptosisERKAktp53p27p21
Abstract
Extracts of Artemisia asiatica Nakai (Asteraceae) possess anti-inflammatory and antioxidative activities. Eupatilin (5,7-dihydroxy-3',4', 6-trimedioxyflavone), one of the pharmacologically active ingredients derived from A. asiatica, was shown to induce apoptosis in human promyelocytic leukemia (HL-60) cells. In the present study, we examined the ability of eupatilin to induce apoptosis in human gastric cancer (AGS) cells. Eupatilin induced the apoptosis of AGS cells as revealed by a decrease in the ratio of pro-apoptotic Bax and anti-apoptotic Bcl-2, as well as the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP). The pro-apoptotic effects of eupatilin were further verified by its perturbation of the mitochondrial transmembrane potential (Delta Psi m). In addition, eupatilin treatment led to an elevated expression of p53 and p21. Eupatilin inhibited the activation of ERK1/2 and Akt, which are important components of cell-survival pathways.
ISSN
0731-8898
URI
https://hdl.handle.net/10371/172785
DOI
https://doi.org/10.1615/JEnvironPatholToxicolOncol.v24.i4.30
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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