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Phloretin Inhibits Phorbol Ester-Induced Tumor Promotion and Expression of Cyclooxygenase-2 in Mouse Skin: Extracellular Signal-Regulated Kinase and Nuclear Factor-kappa B as Potential Targets
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Jun-Wan | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:17:41Z | - |
dc.date.available | 2021-01-31T10:17:41Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | Journal of Medicinal Food, Vol.15 No.3, pp.253-257 | - |
dc.identifier.issn | 1096-620x | - |
dc.identifier.other | 2051 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172795 | - |
dc.description.abstract | The present study investigated the effect of phloretin [2',4',6'-trihydroxy-3-(4-hydroxyphenyl)-propiophenone] on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression and tumor promotion in mouse skin and explored the underlying molecular mechanisms. Topical application of phloretin significantly inhibited 7,12-dimethylbenz[a] anthracene-initiated and TPA-promoted mouse skin carcinogenesis. Pretreatment with phloretin on the dorsal skin of mice inhibited TPA-induced COX-2 expression in a dose-dependent manner. To elucidate the molecular mechanism underlying COX-2 inhibition by phloretin, we examined its effect on TPA-induced activation of nuclear factor-kappa B (NF-kappa B), a ubiquitous transcription factor responsible for TPA-induced COX-2 expression in mouse skin. Topically applied phloretin decreased the TPA-induced DNA binding of NF-kappa B. In addition, phloretin inhibited the phosphorylation as well as the catalytic activity of extracellular signal-regulated kinase (ERK), which was previously found to activate NF-kappa B and induce COX-2 expression in TPA-treated mouse skin. Taken together, the inhibitory effects of phloretin on TPA-induced NF-kappa B activation and COX-2 expression through the modulation of ERK signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis. | - |
dc.language | 영어 | - |
dc.publisher | 한국식품영양과학회 | - |
dc.title | Phloretin Inhibits Phorbol Ester-Induced Tumor Promotion and Expression of Cyclooxygenase-2 in Mouse Skin: Extracellular Signal-Regulated Kinase and Nuclear Factor-kappa B as Potential Targets | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1089/jmf.2011.1851 | - |
dc.citation.journaltitle | Journal of Medicinal Food | - |
dc.identifier.wosid | 000300790500004 | - |
dc.identifier.scopusid | 2-s2.0-84857575682 | - |
dc.citation.endpage | 257 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 253 | - |
dc.citation.volume | 15 | - |
dc.identifier.sci | 000300790500004 | - |
dc.identifier.kciid | ART001645538 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | EPIDERMIS | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | mouse skin carcinogenesis | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | phloretin | - |
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