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Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target
DC Field | Value | Language |
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dc.contributor.author | Woo, Jeong-Hwa | - |
dc.contributor.author | Park, Jong-Min | - |
dc.contributor.author | Jang, Ji-Hye | - |
dc.contributor.author | Yang, Hongkyung | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.date.accessioned | 2021-01-31T10:18:05Z | - |
dc.date.available | 2021-01-31T10:18:05Z | - |
dc.date.created | 2020-11-16 | - |
dc.date.created | 2020-11-16 | - |
dc.date.created | 2020-11-16 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | Journal of Nutritional Biochemistry, Vol.85, p. 108469 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.other | 116343 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172802 | - |
dc.description.abstract | 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the conversion of oncogenic prostaglandin E-2 to non-tumerigenic 15-keto prostaglandin E-2. In the present study, we found that curcumin, a yellow coloring agent present in the rhizome of Curcuma Tonga Linn (Zingiberaceae), induced expression of 15-PGDH at the both transcriptional and translational levels in normal rat gastric mucosal cells. By using deletion constructs of 15-PGDH promoter, we were able to demonstrate that activator protein-1 (AP-1) is the principal transcription factor responsible for regulating curcumin-induced 15-PGDH expression. Curcumin enhanced the expression of c-jun and cFos that are functional subunits of AP-1, in the nuclear fraction of cells. Silencing of c-jun suppressed curcumin-induced expression of 15-PGDH. Moreover, the chromatin immunoprecipitation assay revealed curcumin-induced binding of c-Jun to the AP-1 consensus sequence present in the 15-PGDH promoter. Curaimin increased phosphorylation of ERK1/2 and JNK. and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of clun and 15-PGDH expression. In contrast, tetrahydrocurcumin which lacks the alpha,beta-unsaturated carbonyl group failed to induce 15-PGDH expression, suggesting that the electrophilic carbonyl group of curcumin is essential for its induction of 15-PGDH expression. Curcumin restored the expression of 15-PGDH which is down-regulated by Helicobater pylori through suppression of DNA methyltransferase 1. In addition, oral administration of curcumin increased the expression of 15-PGDH and its regulators such as p-ERK1/2, p-JNK and c-Jun in the mouse stomach. Taken together, these findings suggest that curcumin-induced upregulation of 15-PGDH may contribute to chemopreventive effects of this phytochemical on inflammation-associated gastric carcinogenesis. (C) 2020 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.jnutbio.2020.108469 | - |
dc.citation.journaltitle | Journal of Nutritional Biochemistry | - |
dc.identifier.wosid | 000582520400013 | - |
dc.identifier.scopusid | 2-s2.0-85090244463 | - |
dc.citation.startpage | 108469 | - |
dc.citation.volume | 85 | - |
dc.identifier.sci | 000582520400013 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | FOS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | 15-Hydroxyprostagladin dehydrogenase | - |
dc.subject.keywordAuthor | AP-1 | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Stomach | - |
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