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2-hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Hurh, Yeon-Jin | - |
dc.contributor.author | Chen, Zhi-Hua | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Han, Soon- Young | - |
dc.contributor.author | Surh, YoungJoon | - |
dc.date.accessioned | 2021-01-31T10:18:16Z | - |
dc.date.available | 2021-01-31T10:18:16Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2004-12 | - |
dc.identifier.citation | Journal of Toxicology and Environmental Health - Part A, Vol.67 No.23-24, pp.1939-1953 | - |
dc.identifier.issn | 1528-7394 | - |
dc.identifier.other | 4100 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172805 | - |
dc.description.abstract | Catechol estrogens, the hydroxylated metabolites of 17beta-estradiol (E), have been considered to be implicated in estrogen-induced carcinogenesis. 2-Hydroxyestradiol (2-OHE2), a major oxidized metabolite of E-2 formed preferentially by cytochrome P-450 1A1, reacts with DNA to form stable adducts and exerts genotoxicity. 2-OHE2 can be oxidized to quinone, which is accompanied by generation of reactive oxygen species (ROS). in the present study, 2-OHE2 induced strand scission in Phichi1 74 phage DNA and oxidative base modifications in calf thymus DNA in the presence of cupric ion. In cultured human mammary epithelial (MCF-10A) cells, 2-OHE2 treatment produced ROS accumulation, 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, cytotoxicity, and disruption of mitochondrial transmembrane potential, all of which were prevented by N-acetylcysteine. These findings, taken together, suggest that 2-OHE2-induced oxidative DNA damage and apoptosis in MCF-10A cells might be mediated by ROS generated via the redox cycling of this catechol estrogen. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | 2-hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1080/15287390490514598 | - |
dc.citation.journaltitle | Journal of Toxicology and Environmental Health - Part A | - |
dc.identifier.wosid | 000225105900004 | - |
dc.identifier.scopusid | 2-s2.0-8444245193 | - |
dc.citation.endpage | 1953 | - |
dc.citation.number | 23-24 | - |
dc.citation.startpage | 1939 | - |
dc.citation.volume | 67 | - |
dc.identifier.sci | 000225105900004 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, YoungJoon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MALE SYRIAN-HAMSTERS | - |
dc.subject.keywordPlus | CATECHOL ESTROGENS | - |
dc.subject.keywordPlus | ENDOGENOUS HORMONES | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ESTRADIOL | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | HYDROQUINONE | - |
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