Publications
Detailed Information
Preventive effects of Korean red ginseng on experimentally induced colitis and colon carcinogenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hoon-Jeong | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Zhong, Xiancai | - |
dc.contributor.author | Yum, Hye-Won | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Chun, Kyung-Soo | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:18:26Z | - |
dc.date.available | 2021-01-31T10:18:26Z | - |
dc.date.created | 2020-12-10 | - |
dc.date.created | 2020-12-10 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Journal of Traditional and Complementary Medicine, Vol.10 No.3, pp.198-206 | - |
dc.identifier.issn | 2225-4110 | - |
dc.identifier.other | 118903 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172808 | - |
dc.description.abstract | Korean Red Ginseng (KRG) exerts chemopreventive effects on experimentally induced carcinogenesis through multiple mechanisms. In this study, we investigated effects of KRG on dextran sulfate sodium (DSS)-induced colitis and azoxymethane (AOM) plus DSS-induced colon carcinogenesis in mice. Male C57BL/6J mice were fed diet containing 1% KRG or a standard diet throughout the experiment. The mouse colitis was induced by administration of 3% DSS in drinking water for 1 week. DSS caused body weight loss, diarrhea, rectal bleeding and colon length shortening, and all these symptoms were ameliorated by KRG treatment. KRG inhibited DSS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by suppressing activation of nuclear factor-kappa B (NF-kappa B) and signal transducer and activation of transcription 3 (STAT3). In another experiment, colon carcinogenesis was initiated by single intraperitoneal injection of AOM (10 mg/kg) and promoted by 2% DSS in drinking water. KRG administration relieved the symptoms of colitis and reduced the incidence, the multiplicity and the size of colon tumor. The up-regulation of COX-2, iNOS, c-Myc and Cyclin D1 by AOM plus DSS was attenuated in KRG fed mice which was associated with suppression of NF-kappa B and STAT3 activation. These results suggest that KRG is a potential candidate for chemoprevention of inflammation-associated cancer in the colon. (C) 2020 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Preventive effects of Korean red ginseng on experimentally induced colitis and colon carcinogenesis | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.jtcme.2020.04.004 | - |
dc.citation.journaltitle | Journal of Traditional and Complementary Medicine | - |
dc.identifier.wosid | 000646481100004 | - |
dc.identifier.scopusid | 2-s2.0-85084406855 | - |
dc.citation.endpage | 206 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 198 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NITRIC-OXIDE-SYNTHASE | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | MOUSE COLITIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ATTENUATE | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordAuthor | Korean red ginseng | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | Colon cancer | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | STAT3 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.