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UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Keum, Y. -S. | - |
dc.contributor.author | Kim, H. -G. | - |
dc.contributor.author | Bode, A. M. | - |
dc.contributor.author | Surh, Y. -J. | - |
dc.contributor.author | Dong, Z. | - |
dc.date.accessioned | 2021-01-31T10:19:16Z | - |
dc.date.available | 2021-01-31T10:19:16Z | - |
dc.date.created | 2019-10-18 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | Oncogene, Vol.32 No.4, pp.444-452 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.other | 85271 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172822 | - |
dc.description.abstract | Cyclooxygenase-2 (COX-2) is an inducible enzyme that contributes to the generation of chronic inflammation in response to chemical carcinogens and environmental stresses, including ultraviolet B (UVB) irradiation. Although post-translational histone modifications are believed to have an important role in modulating transcriptional regulation of UVB-induced COX-2, the underlying biochemical mechanisms are completely unknown. Here, we show that UVB activates the p38 MAPK/MSK1 kinase cascade to phosphorylate histone H3 at Ser10 and Ser28, contributing to UVB-induced COX-2 expression. UVB has no effect on the global tri-methylation level of histone H3 (H3K4me3, H3K9me3, and H3K27me3). We observed that selected mammalian 14-3-3 proteins bind to UVB-induced phosphorylated histone H3 (Ser10 and Ser28). In particular, 14-3-3 epsilon is critical for recruiting MSK1 and Cdk9 to the chromatin and subsequently phosphorylating the C-terminal domain of RNA polymerase II in the cox-2 promoter. We propose that histone H3 phosphorylation at Ser10 and Ser28 serve as critical switches to promote cox-2 gene expression by facilitating the recruitment of MSK1 and Cdk9 to the cox-2 promoter, thereby promoting RNA polymerase II phosphorylation. Oncogene (2013) 32, 444-452; doi:10.1038/onc.2012.71; published online 5 March 2012 | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1038/onc.2012.71 | - |
dc.citation.journaltitle | Oncogene | - |
dc.identifier.wosid | 000315551300005 | - |
dc.identifier.scopusid | 2-s2.0-84873059924 | - |
dc.citation.endpage | 452 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 444 | - |
dc.citation.volume | 32 | - |
dc.identifier.sci | 000315551300005 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Y. -J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INDUCED SKIN CARCINOGENESIS | - |
dc.subject.keywordPlus | CHROMOSOME CONDENSATION | - |
dc.subject.keywordPlus | CHROMATIN MODIFICATIONS | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | HETEROCHROMATIN | - |
dc.subject.keywordPlus | ACETYLATION | - |
dc.subject.keywordPlus | IRRADIATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | UVB | - |
dc.subject.keywordAuthor | histone H3 | - |
dc.subject.keywordAuthor | phosphorylation | - |
dc.subject.keywordAuthor | Cdk9 | - |
dc.subject.keywordAuthor | RNA polymerase II | - |
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