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Src-mediated phosphorylation, ubiquitination and degradation of Caveolin-1 promotes breast cancer cell stermness
DC Field | Value | Language |
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dc.contributor.author | Yoon, Hyo-Jin | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Jang, Jeong-Hoon | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:19:22Z | - |
dc.date.available | 2021-01-31T10:19:22Z | - |
dc.date.created | 2019-10-18 | - |
dc.date.created | 2019-10-18 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | Cancer Letters, Vol.449, pp.8-19 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 85264 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172824 | - |
dc.description.abstract | Cancer stem cells (CSCs) are responsible for tumor initiation, metastasis and recurrence. Caveolin-1 (Cav-1) is a major protein of caveolae, which participates in various cellular functions, such as vesicle trafficking, cholesterol homeostasis, tumor progression, etc. In the present study, we investigated a role for Cav-1 in regulating the sternness of human breast cancer (MDA-MB-231) cells. Cav-1 expression was significantly lower in tumorspheres than in adherent cells. The silencing of Cav-1 enhanced sternness of MDA-MB-231 cells. Mechanistically, Cav-1 silencing was accompanied by enhanced expression of Bmi-1, which is a representative self-renewal regulator, and promoted epithelial-mesenchymal transition. In a CSC-like state, reduced Cav-1 depends on its destabilization through ubiquitin-proteasome degradation. We further found that Src-mediated phosphorylation of Cav-1 at the Tyr 14 residue is essential for its degradation. Taken together, these findings suggest that Cav-1 destabilization by Src may play a pivotal role in manifestation and maintenance of sternness in breast cancer cells. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Src-mediated phosphorylation, ubiquitination and degradation of Caveolin-1 promotes breast cancer cell stermness | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.canlet.2019.01.021 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000463130200002 | - |
dc.identifier.scopusid | 2-s2.0-85061767425 | - |
dc.citation.endpage | 19 | - |
dc.citation.startpage | 8 | - |
dc.citation.volume | 449 | - |
dc.identifier.sci | 000463130200002 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITIONS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | TYROSINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | ANOIKIS | - |
dc.subject.keywordAuthor | Breast cancer stem cell | - |
dc.subject.keywordAuthor | Caveolin-1 | - |
dc.subject.keywordAuthor | c-Src | - |
dc.subject.keywordAuthor | Phosphorylation | - |
dc.subject.keywordAuthor | Destabilization | - |
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