Browse

High-fat diet stimulates IL-1 type I receptor-mediated inflammatory signaling in the skeletal muscle of mice

Cited 13 time in Web of Science Cited 13 time in Scopus
Authors
Kim, Seung-Jin; Choi, Youngshim; Jun, Hye-Seung; Kim, Bo-Min; Na, Hye-Kyung; Surh, Young-Jun; Park, Taesun
Issue Date
2010-07
Citation
Molecular Nutrition and Food Research, Vol.54 No.7, pp.1014-1020
Keywords
IL-1 type I receptorInhibitor of kappa B kinaseMetaflammationMyD88Nuclear factor kappa B
Abstract
Recently, substantial attention has been focused on the association between obesity and chronic inflammation. The aim of the present study was to investigate whether high-fat diet (HFD)-induced obesity induces the activation of the IL-1 type I receptor (IL-1RI)-mediated inflammatory signaling cascade in the skeletal muscle of mice. Male C57BL/6J mice were fed either an HFD or a normal diet (ND) for 12 wk. Compared with the results in mice receiving the ND, the HFD increased the expression of IL-1RI and downstream signaling proteins, such as myeloid differentiation primary response gene 88 (MyD88), IL-1R-associated kinase 4 and phospho-transforming growth factor-activated kinase 1 in the skeletal muscle. Additionally, activities of both inhibitor of kappa B kinase beta and inhibitor of kappa B degradation were significantly elevated in the skeletal muscle of mice fed with an HFD compared with mice receiving an ND. In contrast, the levels of other downstream transcription factors, such as activator protein-1 and INF regulatory factor 5, were not affected by the HFD. These results suggest that the IL-1RI-MyD88-nuclear factor kappa B signaling pathway might be involved in the induction of the inflammatory response in the skeletal muscle of mice fed with an HFD.
ISSN
1613-4125
URI
https://hdl.handle.net/10371/172830
DOI
https://doi.org/10.1002/mnfr.200800512
Files in This Item:
There are no files associated with this item.
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse