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Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion : Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappa B activation and tumor promotion
DC Field | Value | Language |
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dc.contributor.author | Keum, Young-Sam | - |
dc.contributor.author | Han, Seong Su | - |
dc.contributor.author | Chun, Kyung-Soo | - |
dc.contributor.author | Park, Kwang-Kyun | - |
dc.contributor.author | Park, Jeong-Hill | - |
dc.contributor.author | Lee, Seung Ki | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:20:08Z | - |
dc.date.available | 2021-01-31T10:20:08Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2003-02 | - |
dc.identifier.citation | Mutation Research, Vol.523, pp.75-85 | - |
dc.identifier.issn | 0027-5107 | - |
dc.identifier.other | 4496 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172836 | - |
dc.description.abstract | Our previous studies demonstrated the anti-oxidant and anti-tumor promotional properties of the methanol extract of heat-processed Panax ginseng C.A. Meyer [Cancer Lett. 150 (2000) 41]. In the present work, we have evaluated anti-inflammatory as well as anti-tumor promoting effects of Rg(3), a major ginsenoside derived from heat-processed ginseng. Pretreatment of dorsal skins of female ICR mice with Rg(3) significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase activity and 7,12-dimethylbenz[a] anthracene-initiated papilloma formation. In another experiment, Rg(3) pretreatment abrogated the expression of cyclooxygenase-2 in TPA-stimulated mouse skin. Rg(3) also inhibited the TPA-induced activation of the eukaryotic transcription factor, NF-kappaB in both mouse skin and cultured human pro-myelocytic leukemia (HL-60) cells. Moreover, Rg(3) exerted potent inhibitory effects on the activation of another transcription factor, activator protein-1 (AP-1) that is responsible for c-jun and c-fos oncogenic transactivation. Based on these findings, it is likely that the anti-tumor promoting activity of Rg(3) is mediated possibly through down-regulation of NF-kappaB and AP-1 transcription factors. (C) 2002 Elsevier Science B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion | - |
dc.title.alternative | Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappa B activation and tumor promotion | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0027-5107(02)00323-8 | - |
dc.citation.journaltitle | Mutation Research | - |
dc.identifier.wosid | 000181733900008 | - |
dc.identifier.scopusid | 2-s2.0-0037293063 | - |
dc.citation.endpage | 85 | - |
dc.citation.startpage | 75 | - |
dc.citation.volume | 523 | - |
dc.identifier.sci | 000181733900008 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Jeong-Hill | - |
dc.contributor.affiliatedAuthor | Lee, Seung Ki | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ORNITHINE DECARBOXYLASE ACTIVITY | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ANCHORAGE-INDEPENDENT GROWTH | - |
dc.subject.keywordPlus | MOUSE SKIN CARCINOGENESIS | - |
dc.subject.keywordPlus | BREAST EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | CONSTITUTIVE ACTIVATION | - |
dc.subject.keywordAuthor | anti-tumor promotion | - |
dc.subject.keywordAuthor | AP-1 | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | ginseng | - |
dc.subject.keywordAuthor | ginsenoside Rg(3) | - |
dc.subject.keywordAuthor | HL-60 cells | - |
dc.subject.keywordAuthor | mouse skin carcinogenesis | - |
dc.subject.keywordAuthor | NF-kappa B | - |
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