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Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice
DC Field | Value | Language |
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dc.contributor.author | Murakami, Akira | - |
dc.contributor.author | Tanaka, Takuji | - |
dc.contributor.author | Lee, Ji‐Yoon | - |
dc.contributor.author | Surh, Young‐Joon | - |
dc.contributor.author | Kim, Ha Won | - |
dc.contributor.author | Kawabata, Kyuichi | - |
dc.contributor.author | Nakamura, Yoshimasa | - |
dc.contributor.author | Jiwajinda, Suratwadee | - |
dc.contributor.author | Ohigashi, Hajime | - |
dc.date.accessioned | 2021-01-31T10:20:12Z | - |
dc.date.available | 2021-01-31T10:20:12Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2004-07 | - |
dc.identifier.citation | International Journal of Cancer, Vol.110 No.4, pp.481-490 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.other | 4175 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172837 | - |
dc.description.abstract | We recently showed that zerumbone, a sesquiterpene found in subtropical ginger, suppresses colonic tumor marker formation in rats and induces apoptosis in colon cancer cell lines. In our present study, the anti-tumor initiating and promoting activities of zerumbone in mouse skin were evaluated using a conventional 2-stage carcinogenesis model. A single topical pretreatment to mouse skin (2 mumol) 24 hr before application of dimethylbenz[a]anthracene (0.2 mumol) markedly suppressed tumor incidence by 60% and the number of tumors by 80% per mouse. Repeated pretreatment (16 nmol) twice weekly during the post-initiation phase reduced the number of 12-O-tetradecanoylphorbol-13-acetate (TPA, 1.6 nmol)-induced tumors by 83% as well as their diameter by 57%. Multiple reverse transcriptase (RT) PCR experiments revealed that zerumbone (2 mumol) enhanced the mRNA expression level of manganese superoxide dismutase, glutathione peroxidase-1, glutathione S-transferase-P1 and NAD(P)H quinone oxidoreductase in the epidermis, but not that of cytochrome P450 1A1 or 1B1. Further, it diminished TPA-induced cyclooxygenase-2 protein expression and phosphorylation of extracellular signal-regulated kinase 1/2, while pretreatment(s), in either the priming or activation stage or both, reduced double TPA application-induced hydrogen peroxide formation and edema induction by 29% to 86%, respectively. Histologic examination revealed that pretreatment(s) with zerumbone suppressed leukocyte infiltration and reduced proliferating cell nuclear antigen-labeling indices. Together, our results indicate that zerumbone is a promising agent for the prevention of both tumor initiating and promoting processes, through induction of anti-oxidative and phase II drug metabolizing enzymes as well as attenuation of proinflammatory signaling pathways. (C) 2004 Wiley-Liss, Inc. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1002/ijc.20175 | - |
dc.citation.journaltitle | International Journal of Cancer | - |
dc.identifier.wosid | 000221586700003 | - |
dc.identifier.scopusid | 2-s2.0-2442654176 | - |
dc.citation.endpage | 490 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 481 | - |
dc.citation.volume | 110 | - |
dc.identifier.sci | 000221586700003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young‐Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CYP1B1 DETERMINES SUSCEPTIBILITY | - |
dc.subject.keywordPlus | ESTER-INDUCED EXPRESSION | - |
dc.subject.keywordPlus | ABERRANT CRYPT FOCI | - |
dc.subject.keywordPlus | P38 MAP KINASES | - |
dc.subject.keywordPlus | MOUSE SKIN | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PHORBOL ESTER | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordAuthor | zerumbone | - |
dc.subject.keywordAuthor | 12-O-teradecanoylphorbol-13-acetate | - |
dc.subject.keywordAuthor | 7,12-dimethylbenz[a]anthracene | - |
dc.subject.keywordAuthor | xenobiotic enzyme | - |
dc.subject.keywordAuthor | cyclooxygense-2 | - |
dc.subject.keywordAuthor | oxidative stress | - |
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