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Effects of cyclopentenone prostaglandins on the expression of heme oxygenase-1 in MCF-7 cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eun‐Hee | - |
dc.contributor.author | Kim, Do‐Hee | - |
dc.contributor.author | Na, Hye‐Kyung | - |
dc.contributor.author | Surh, Young‐Joon | - |
dc.date.accessioned | 2021-01-31T10:20:42Z | - |
dc.date.available | 2021-01-31T10:20:42Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Annals of the New York Academy of Sciences, Vol.1030, pp.493-500 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.other | 4306 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172844 | - |
dc.description.abstract | Cyclopentenone prostaglandins (cyPGs) are produced by dehydration of precursor molecules. The cyPGs are reported to have proapoptotic effects in a variety of cell types. However, cyPGs, particularly 15-deoxy-Delta(12,14)- prostaglandin J(2) (15d-PGJ(2)), can also exert cytoprotective effects at relatively low concentrations. The cytoprotective activity of cyPGs appears to be mediated by the reactive alpha,beta-unsaturated carbonyl group located in the cyclopentene ring. In this study, we investigated the effect of cyPGs on the expression of heme oxygenase-1 (HO-1), a ubiquitous stress-responsive enzyme that catalyzes oxidative cleavage of heme to form iron, carbon monoxide, and biliverdin. Treatment of the human breast cancer cell line (MCF-7) with 15d-PGJ(2) resulted in a concentration- and time-dependent increase in the expression of HO-1, whereas prostaglandin A(2) (PGA(2)) and the non-PG derivative 2-cyclopenten-1-one failed to induce HO-1 expression at the protein level. RT-PCR revealed that the expression of HO-1 mRNA was induced at 6 h by 15d-PGJ(2) at 10 mu M. However, PGA(2) induced HO-1 mRNA expression at a higher concentration (30 mu M). 2-Cyclopenten-1-one did not induce the expression of HO-1 mRNA at all. Likewise, 15d-PGJ(2) treatment for 6 h led to phosphorylation of Akt/protein kinase B (PKB) to a greater extent than that achieved with PGA(2). Thus, the induction of HO-1 expression and the activation of Akt/PKB by 15d-PGJ(2) and PGA(2) are likely to confer cytoprotective or antiapoptotic effects exerted by these cyPGs. | - |
dc.language | 영어 | - |
dc.publisher | New York Academy of Sciences | - |
dc.title | Effects of cyclopentenone prostaglandins on the expression of heme oxygenase-1 in MCF-7 cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1196/annals.1329.061 | - |
dc.citation.journaltitle | Annals of the New York Academy of Sciences | - |
dc.identifier.wosid | 000228128100060 | - |
dc.identifier.scopusid | 2-s2.0-15044345354 | - |
dc.citation.endpage | 500 | - |
dc.citation.startpage | 493 | - |
dc.citation.volume | 1030 | - |
dc.identifier.sci | 000228128100060 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young‐Joon | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR NRF2 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN-J(2) | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | cyclopentenone prostaglandins | - |
dc.subject.keywordAuthor | heme oxygenase-1 | - |
dc.subject.keywordAuthor | cytoprotective effect | - |
dc.subject.keywordAuthor | Akt/PKB | - |
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