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Inhibition of human breast cancer growth by GCp™ (genistein combined polysaccharide) in xenogeneic athymic mice: Involvement of genistein biotransformation by β-glucuronidase from tumor tissues

Cited 29 time in Web of Science Cited 38 time in Scopus
Authors
Yuan, Lan; Wagatsuma, Chihiro; Yoshida, Mayumi; Miura, Takehito; Mukoda, Tomomi; Fujii, Hajime; Sun, Buxiang; Kim, Jung-Hwan; Surh, Young-Joon
Issue Date
2003-02
Citation
Mutation Research, Vol.523, pp.55-62
Keywords
genisteinbreast cancerathymic micebeta-glucuronidaseapoptosis
Abstract
The role of beta-glucuronidase in genistein biotransformation was investigated in a human breast cancer MDA-MB-231 xenogeneic athymic mouse model. Genistein combined polysaccharide (GCP(TM), a genistein aglycone rich functional food supplement was used in these experiments. Tumor-bearing mice were subjected to oral administration of GCP(TM) for 28 days. GCP(TM) treatment significantly inhibited tumor growth. Induction of apoptosis by GCP(TM) treatment was related to activation of cleavage of poly (ADP-ribose)polymerase, induction of the p21 protein expression and reduction of cyclin B1 expression in the tumor tissues. Genistein exists as a glucuronide conjugate in normal organ tissues, and the conjugated genistein lacks the physiological activity of the aglycone. Tumor tissues contain large amounts of beta-glucuronidase, the enzyme that converts the genistein beta-glucuronide conjugate into genistein aglycone. The resulting genistein aglycone exerts its chemopreventive activities, including the induction of apoptosis in tumor tissues, and, finally, leads to tumor growth inhibition. (C) 2002 Elsevier Science B.V. All rights reserved.
ISSN
0027-5107
URI
https://hdl.handle.net/10371/172849
DOI
https://doi.org/10.1016/S0027-5107(02)00321-4
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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