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Antioxidative and antitumor promoting effects of [6]-paradol and its homologs
DC Field | Value | Language |
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dc.contributor.author | Chung, Won-Yoon | - |
dc.contributor.author | Jung, Yeon-Joo | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Lee, Sang-Sup | - |
dc.contributor.author | Park, Kwang-Kyun | - |
dc.date.accessioned | 2021-01-31T10:21:45Z | - |
dc.date.available | 2021-01-31T10:21:45Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2001-09 | - |
dc.identifier.citation | Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol.496 No.1-2, pp.199-206 | - |
dc.identifier.issn | 1383-5718 | - |
dc.identifier.other | 4797 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172862 | - |
dc.description.abstract | Recently, considerable attention is focused on anti-carcinogenic phytochemicals, particularly those derived from medicinal or edible plants. [6]-Paradol, a pungent phenolic compound present in certain Zingiberaceae plants, is known to have antimicrobial and analgesic activities. The compound has been reported to attenuate promotion of skin carcinogenesis and TPA-induced ear edema in female ICR mice, and to induce apoptosis in cultured human promyelocytic leukemia (HL-60) cells. In this study, we performed several biochemical studies to evaluate and compare the cancer chemopreventive potential of [6]-paradol and its synthetic derivatives. [6]-Paradol and its synthetic nonpungent analog, [6]-dehydroparadol significantly decreased the incidence and the multiplicity of skin tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-0-tetradecanoylphorbol-13-acetate (TPA). Topical application of [6]-paradol and its derivatives inhibited TPA-induced ear edema and H2O2 production and myeloperoxidase activity in the dorsal skin of mice. Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H2O2- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds. These results indicate that [6]-paradol and its derivatives possess the cancer chemopreventive potential. (C) 2001 Elsevier Science B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Antioxidative and antitumor promoting effects of [6]-paradol and its homologs | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S1383-5718(01)00221-2 | - |
dc.citation.journaltitle | Mutation Research - Genetic Toxicology and Environmental Mutagenesis | - |
dc.identifier.wosid | 000170481900023 | - |
dc.identifier.scopusid | 2-s2.0-0035922173 | - |
dc.citation.endpage | 206 | - |
dc.citation.number | 1-2 | - |
dc.citation.startpage | 199 | - |
dc.citation.volume | 496 | - |
dc.identifier.sci | 000170481900023 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Sup | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EPIDERMAL ORNITHINE DECARBOXYLASE | - |
dc.subject.keywordPlus | CANCER CHEMOPREVENTIVE ACTIVITY | - |
dc.subject.keywordPlus | SKIN TUMOR PROMOTION | - |
dc.subject.keywordPlus | SENCAR MOUSE SKIN | - |
dc.subject.keywordPlus | INDUCED INFLAMMATION | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | DIETARY | - |
dc.subject.keywordPlus | 12-O-TETRADECANOYLPHORBOL-13-ACETATE | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | INITIATION | - |
dc.subject.keywordAuthor | [6]-paradol | - |
dc.subject.keywordAuthor | [6]-dehydroparadol | - |
dc.subject.keywordAuthor | vanilloids | - |
dc.subject.keywordAuthor | mouse skin carcinogenesis | - |
dc.subject.keywordAuthor | ornithine decarboxylase | - |
dc.subject.keywordAuthor | antitumor promoting activity | - |
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