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Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-κB and ERK1/2 in mouse skin

Cited 44 time in Web of Science Cited 53 time in Scopus
Authors
Surh, Young-Joon; Lee, Ji-Yoon; Choi, Kang-Ju; Ko, Sung-Ryong
Issue Date
2002-11
Citation
Annals of the New York Academy of Sciences, Vol.973, pp.396-401
Keywords
ginsenosidescyclooxygenase-2nuclear factor-kappa BERK1/2phytochemicalsPanax ginseng
Abstract
Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb-1, Rc, Re, Rg(1), Rg(3)) derived from P ginseng. Topical application of each of these ginsenosides significantly attenuated ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). These ginsenosides also suppressed expression of cyclooxygenase-2 (COX-2) and activation of NF-kappaB in the TPA-treated dorsal skin of mice. Of the ginsenosides tested, Rg(3) Was found to be most effective in terms of inhibiting TPA-induced ear edema, COX-2 expression, and NF-kappaB activation.
ISSN
0077-8923
URI
https://hdl.handle.net/10371/172873
DOI
https://doi.org/10.1111/j.1749-6632.2002.tb04672.x
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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