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Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells

Cited 68 time in Web of Science Cited 80 time in Scopus
Authors
Keum, Young-Sam; Kim, Jin; Lee, Keun Hyung; Park, Kwang Kyun; Surh, Young-Joon; Lee, Jong Min; Lee, Sang-Sup; Yoon, Jung Hoon; Joo, So Yeon; Cha, In Ho; Yook, Jong In
Issue Date
2002-03
Citation
Cancer Letters, Vol.177 No.1, pp.41-47
Keywords
[6]-paradolapoptosisKB cellscaspase-3
Abstract
[6]-paradol, a pungent phenolic substance found in ginger and other Zingiberaceae plants, has been demonstrated to be an effective inhibitor of tumor promotion in mouse skin carcinogenesis. In the present study, we found that [6]-paradol and other structurally related derivatives, [10]-paradol, [3]-dehydroparadol, [6]-dehydroparadol, and [10]-dehydroparadol, with the exception of [3]-paradol induce apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. [10]paradol and [10]-dehydroparadol exhibited a similar extent of cytotoxicity to that of [6]-paradol. [6]-Dehydroparadol and [3]dehydroparadol appeared to be more potent, with an IC50 less than 40 muM. Treatment of KB cells with an apoptosis-inducing concentration of [6]-dehydroparadol caused induction of proteolytic cleavage of pro-caspase-3. These results suggest that [6]paradol and structurally related derivatives induce apoptosis through a caspase-3-dependent mechanism. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172877
DOI
https://doi.org/10.1016/S0304-3835(01)00781-9
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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