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Inhibition by chlorophyllin of forward and reverse bacterial mutagenicity of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide

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Authors
Surh, Young‐Joon
Issue Date
1998-12
Citation
Phytotherapy Research, Vol.12 No.8, pp.580-583
Keywords
chlorophyllinantimutagenesisbenzo[a]pyrene-diolepoxidechemoprevention
Abstract
Chlorophyllin (CHL), a water soluble derivative of the green pigment chlorophyll, was evaluated for its antimutagenic activity towards benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). CHL suppressed dose-dependently the formation of 8-azaguanine-resistant mutant colonies in Salmonella typhimarium TM677 treated with BPDE, Under the same experimental conditions, the cytotoxicity of this direct-acting mutagen was concomitantly blunted by CHL. The protective effect of CHL against BPDE mutagenicity was confirmed in the Salmonella histidine(+) reversion assay CHL also reduced the in vitro covalent binding of BPDE to DNA. (C) 1998 John Wiley & Sons, Ltd.
ISSN
0951-418X
URI
https://hdl.handle.net/10371/172889
DOI
https://doi.org/10.1002/(SICI)1099-1573(199812)12:8<580::AID-PTR364>3.0.CO;2-F
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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