S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Capsaicin suppresses phorbol ester-induced activation of NF-kappa B/Rel and AP-1 transcription factors in mouse epidermis
- Han, Seung Su; Keum, Young-Sam; Seo, Hyo-Joung; Chun, Kyung-Soo; Lee, Sang Sup; Surh, Young-Joon
- Issue Date
- Cancer Letters, Vol.164 No.2, pp.119-126
- capsaicin; NF-kappa B; activator protein 1; transcription factor; mouse skin carcinogenesis; tumor promotion
- Capsaicin, the principal pungent ingredient of hot chili peppers, has anti-inflammatory and analgesic properties and is currently used as a topical cream for the management of various neuropathic conditions. In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of I kappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65. Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment. Since altered transactivation of NF-kappaB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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